Tbio BTLA B- and T-lymphocyte attenuator

Protein Summary

Description

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q7Z6A9
• Q3B831
• Q3HS85
• Q6ZNH9

Gene Name

• BTLA

Ensembl ID

• ENST00000334529
• ENSP00000333919
• ENSG00000186265
• ENST00000383680
• ENSP00000373178

Symbol

• BTLA1
• CD272

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.69
PubMedID	0.63
tissue sample	0.59
microRNA	0.55
biological term	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.12   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 751   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.12   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0