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Tclin
BTK
Tyrosine-protein kinase BTK

Protein Summary
Description
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. E ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308731
  • ENSP00000308176
  • ENSG00000010671
  • ENST00000621635
  • ENSP00000483570

Symbol
  • AGMX1
  • ATK
  • BPK
  • AT
  • ATK
  • BPK
  • XLA
  • IMD1
  • AGMX1
  • IGHD3
  • PSCTK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
biological process
0.99
kinase
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2165.85   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 1116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2165.85   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 1116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1574
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (321)
HSP90AB3P
Tdark
p_int:  0.999985699
p_ni:  0.000014121
p_wrong:  1.79e-7
Data Source:  BioPlex
ANKRD54
Tbio
Novelty:  0.03101679
p_int:  0.999970474
p_ni:  7.84e-7
p_wrong:  0.000028742
Score:  0.442
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.996691513
p_ni:  0.00321431
p_wrong:  0.000094176
Score:  0.228
Data Source:  BioPlex,STRINGDB
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
p_int:  0.971403551
p_ni:  0.027923846
p_wrong:  0.000672603
Score:  0.388
Data Source:  BioPlex,STRINGDB
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.94713995
p_ni:  0.05286005
Score:  0.239
Data Source:  BioPlex,STRINGDB
KATNB1
Tbio
Novelty:  0.08472625
p_int:  0.826265473
p_ni:  0.173734506
p_wrong:  2.1e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
p_int:  0.812506303
p_ni:  0.187493697
Score:  0.479
Data Source:  BioPlex,STRINGDB
SH3BP5
Tbio
Novelty:  0.00597871
Score:  0.994
Data Source:  STRINGDB
BLNK
Tbio
Novelty:  0.00351169
Score:  0.992
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.991
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (63)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
DAP12 interactions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
DAP12 interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88216
12229
Rat
RGD:1359683
367901
Dog
Bruton tyrosine kinase
VGNC:38560
492019
Horse
Bruton tyrosine kinase
VGNC:15920
100057626
Cow
Bruton tyrosine kinase
VGNC:26601
533459
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Bruton tyrosine kinase
Horse
Bruton tyrosine kinase
Cow
Bruton tyrosine kinase
Publication Statistics
PubMed Score 2165.85
PubMed score by year
PubTator Score 1000.97
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title