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Tclin
BTK
Tyrosine-protein kinase BTK

Protein Summary
Description
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. E ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308731
  • ENSP00000308176
  • ENSG00000010671
  • ENST00000621635
  • ENSP00000483570

Symbol
  • AGMX1
  • ATK
  • BPK
  • AT
  • ATK
  • BPK
  • XLA
  • IMD1
  • AGMX1
  • IGHD3
  • PSCTK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
1
biological process
0.99
kinase
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3021.72   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 1116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3021.72   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 1116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1762
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7