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Tbio
BTG3
Protein BTG3

Protein Summary
Description
Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase. The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339775
  • ENSP00000344609
  • ENSG00000154640
  • ENST00000348354
  • ENSP00000284879

Symbol
  • ANA
  • TOB5
  • ANA
  • TOB5
  • TOFA
  • APRO4
  • TOB55
  • ANA/BTG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
kinase perturbation
0.95
PubMedID
0.7
small molecule perturbation
0.7
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.63   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.63   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.99999788
p_ni:  0.00000212
Score:  0.687
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999994853
p_ni:  0.000005147
p_wrong:  1e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999937004
p_ni:  0.000061724
p_wrong:  0.000001272
Score:  0.808
Data Source:  BioPlex,STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.999928096
p_ni:  0.000071882
p_wrong:  2.3e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999783201
p_ni:  0.000216788
p_wrong:  1.1e-8
Score:  0.812
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999273122
p_ni:  0.000266788
p_wrong:  0.00046009
Data Source:  BioPlex
TEX13A
Tdark
Novelty:  1.13928013
p_int:  0.999255458
p_ni:  0.000744542
Score:  0.672
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999054789
p_ni:  0.000537666
p_wrong:  0.000407545
Score:  0.187
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.998107985
p_ni:  0.00176314
p_wrong:  0.000128875
Data Source:  BioPlex
CNOT8
Tbio
Novelty:  0.01700084
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
53.2
leukocyte count
1
1
1
18.4
intelligence
1
1
1
8.5
educational attainment
1
1
1
7.3
feeling emotionally hurt measurement
1
1
0
5.9
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
53.2
leukocyte count
1
18.4
intelligence
1
8.5
educational attainment
1
7.3
feeling emotionally hurt measurement
0
5.9
4.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTG anti-proliferation factor 3
VGNC:3745
749692
Macaque
BTG anti-proliferation factor 3
710579
Mouse
MGI:109532
12228
Rat
RGD:2226
54230
Dog
BTG anti-proliferation factor 3
VGNC:38559
487695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTG anti-proliferation factor 3
Macaque
BTG anti-proliferation factor 3
Mouse
Rat
Dog
BTG anti-proliferation factor 3
Publication Statistics
PubMed Score 215.63
PubMed score by year
PubTator Score 46.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title