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Tdark
BTBD6
BTB/POZ domain-containing protein 6

Protein Summary
Description
Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327471
  • ENSP00000329361
  • ENSG00000184887
  • ENST00000392554
  • ENSP00000376337
  • ENST00000463376
  • ENSP00000418150
  • ENST00000536364
  • ENSP00000443091

Symbol
  • BDPL
  • BDPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
protein domain
0.73
kinase perturbation
0.71
tissue sample
0.68
cell type or tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (328)
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.999992792
p_ni:  0.00000174
p_wrong:  0.000005468
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999329763
p_ni:  0.000670237
Score:  0.93
Data Source:  BioPlex,STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.863722807
p_ni:  0.040844167
p_wrong:  0.095433026
Score:  0.226
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.981
Data Source:  STRINGDB
ZBTB16
Tbio
Family:  TF
Novelty:  0.0034205
Score:  0.966
Data Source:  STRINGDB
UNKL
Tdark
Family:  Enzyme
Novelty:  1.37466055
Score:  0.941
Data Source:  STRINGDB
FEM1C
Tbio
Novelty:  0.09385738
Score:  0.932
Data Source:  STRINGDB
CAND1
Tbio
Novelty:  0.0196525
Score:  0.929
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.917
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
4
4
98.3
platelet count
4
4
4
96.3
reticulocyte measurement
3
3
3
85.6
reticulocyte count
2
2
2
82.8
mean corpuscular volume
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
98.3
platelet count
4
96.3
reticulocyte measurement
3
85.6
reticulocyte count
2
82.8
mean corpuscular volume
1
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BTB domain containing 6
106999595
Mouse
MGI:3026623
399566
Rat
RGD:1597323
690367
Dog
BTB domain containing 6
VGNC:38553
102152663
Horse
BTB domain containing 6
VGNC:15912
102150846
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BTB domain containing 6
Mouse
Rat
Dog
BTB domain containing 6
Horse
BTB domain containing 6
Publication Statistics
PubMed Score 3.87
PubMed score by year
PubTator Score 1.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title