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Tbio
BTBD2
BTB/POZ domain-containing protein 2

Protein Summary
Description
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
histone modification site profile
0.65
tissue sample
0.64
hub protein
0.63
cell line
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.999631939
p_ni:  0.000368061
Score:  0.915
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.984392619
p_ni:  0.015607381
Score:  0.83
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.904048409
p_ni:  0.095951591
Score:  0.823
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.901424041
p_ni:  0.098575959
Score:  0.828
Data Source:  BioPlex,STRINGDB
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.89040426
p_ni:  0.10959574
Score:  0.825
Data Source:  BioPlex,STRINGDB
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.78677288
p_ni:  0.21322712
Score:  0.831
Data Source:  BioPlex,STRINGDB
TOP1
Tclin
Family:  Enzyme
Novelty:  0.00019573
Score:  0.949
Data Source:  STRINGDB
TRIM5
Tbio
Novelty:  0.00289445
Score:  0.931
Data Source:  STRINGDB
CLUL1
Tdark
Novelty:  0.278839
Score:  0.694
Data Source:  STRINGDB
WDSUB1
Tdark
Novelty:  0.59347219
Score:  0.69
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
75.4
red blood cell distribution width
2
1
2
71.9
BMI-adjusted hip circumference
1
1
1
64.9
body mass index
1
1
1
54.4
mean platelet volume
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
75.4
red blood cell distribution width
2
71.9
BMI-adjusted hip circumference
1
64.9
body mass index
1
54.4
mean platelet volume
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BTB domain containing 2
721419
Mouse
MGI:1933831
208198
Rat
RGD:1566094
500793
Dog
BTB domain containing 2
VGNC:54579
485074
Opossum
BTB domain containing 2
100018923
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BTB domain containing 2
Mouse
Rat
Dog
BTB domain containing 2
Opossum
BTB domain containing 2
Publication Statistics
PubMed Score 3.85
PubMed score by year
PubTator Score 3.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title