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Tbio
BTBD10
BTB/POZ domain-containing protein 10

Protein Summary
Description
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278174
  • ENSP00000278174
  • ENSG00000148925
  • ENST00000530907
  • ENSP00000431186

Symbol
  • GMRP1
  • GMRP1
  • GMRP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
virus perturbation
0.72
transcription factor binding site profile
0.68
tissue sample
0.61
cell type or tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
BUB3
Tbio
Novelty:  0.00714143
p_int:  0.99999857
p_ni:  0.000001105
p_wrong:  3.25e-7
Score:  0.527
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999998488
p_ni:  0.00000151
p_wrong:  1e-9
Score:  0.235
Data Source:  BioPlex,STRINGDB
SRSF3
Tbio
Novelty:  0.01015895
Score:  0.68
Data Source:  STRINGDB
TAF1B
Tbio
Family:  Enzyme
Novelty:  0.10174314
Score:  0.663
Data Source:  STRINGDB
MRPS35
Tdark
Novelty:  6.44240335
Score:  0.62
Data Source:  STRINGDB
GPN2
Tdark
Family:  Enzyme
Novelty:  0.26461894
Score:  0.571
Data Source:  STRINGDB
CPPED1
Tbio
Family:  Enzyme
Novelty:  0.10475831
Score:  0.557
Data Source:  STRINGDB
TACO1
Tbio
Family:  Enzyme
Novelty:  0.10710318
Score:  0.554
Data Source:  STRINGDB
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
Score:  0.542
Data Source:  STRINGDB
PTH2
Tdark
Novelty:  0.0288995
Score:  0.54
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
3
6
97.4
triglyceride measurement
7
4
8
94.1
calcium measurement
3
3
3
91.4
body mass index
4
4
4
90.4
age at menarche
1
1
1
84.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
97.4
triglyceride measurement
8
94.1
calcium measurement
3
91.4
body mass index
4
90.4
age at menarche
1
84.5
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 10
VGNC:7645
451035
Macaque
BTB domain containing 10
700325
Mouse
MGI:1916065
68815
Rat
RGD:1306301
308890
Dog
BTB domain containing 10
VGNC:38546
476861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 10
Macaque
BTB domain containing 10
Mouse
Rat
Dog
BTB domain containing 10
Publication Statistics
PubMed Score 7.52
PubMed score by year
PubTator Score 5.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title