You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BTBD1
BTB/POZ domain-containing protein 1

Protein Summary
Description
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity). The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261721
  • ENSP00000261721
  • ENSG00000064726
  • ENST00000379403
  • ENSP00000368713

Symbol
  • C15orf1
  • NS5ATP8
  • C15orf1
  • NS5ATP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
disease perturbation
0.87
transcription factor perturbation
0.84
kinase perturbation
0.81
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.12   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.12   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (373)
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.999997545
p_ni:  0.000002455
Score:  0.961
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999996766
p_ni:  0.000003234
Score:  0.966
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.999996397
p_ni:  0.000003603
Score:  0.973
Data Source:  BioPlex,STRINGDB
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.999991722
p_ni:  0.000008278
Score:  0.962
Data Source:  BioPlex,STRINGDB
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.999966782
p_ni:  0.000033218
Score:  0.965
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999924026
p_ni:  0.000075974
Score:  0.963
Data Source:  BioPlex,STRINGDB
BTBD2
Tbio
Novelty:  0.23314987
p_int:  0.999631939
p_ni:  0.000368061
Score:  0.915
Data Source:  BioPlex,STRINGDB
PNMA1
Tbio
Novelty:  0.06899807
p_int:  0.997904903
p_ni:  0.00209347
p_wrong:  0.000001627
Score:  0.19
Data Source:  BioPlex,STRINGDB
FAM98A
Tbio
Novelty:  0.30067413
p_int:  0.997665181
p_ni:  0.002303372
p_wrong:  0.000031447
Score:  0.173
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.997314071
p_ni:  0.002685929
Score:  0.96
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
2
3
52
lymphocyte count
1
1
1
48.8
glomerular filtration rate
2
1
2
45
1
1
0
1.1
41.8
basophil count
1
1
1
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
52
lymphocyte count
1
48.8
glomerular filtration rate
2
45
0
1.1
41.8
basophil count
1
5.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 1
VGNC:7768
453599
Mouse
MGI:1933765
83962
Rat
RGD:1310962
293060
Dog
BTB domain containing 1
VGNC:38545
479057
Horse
BTB domain containing 1
VGNC:15907
100068143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTB domain containing 1
Mouse
Rat
Dog
BTB domain containing 1
Horse
BTB domain containing 1
Publication Statistics
PubMed Score 6.12
PubMed score by year
PubTator Score 2.08
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title