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Tbio
BST1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Protein Summary
Description
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265016
  • ENSP00000265016
  • ENSG00000109743

Symbol
  • CD157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.79
histone modification site profile
0.63
tissue sample
0.63
kinase perturbation
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.58   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.58   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
PPCS
Tbio
Family:  Enzyme
Novelty:  0.03813202
p_int:  0.999941871
p_ni:  0.000058127
p_wrong:  2e-9
Data Source:  BioPlex
PRSS21
Tbio
Family:  Enzyme
Novelty:  0.0110251
p_int:  0.999795291
p_ni:  0.000009062
p_wrong:  0.000195647
Score:  0.9
Data Source:  BioPlex,STRINGDB
DHODH
Tclin
Family:  Enzyme
Novelty:  0.00217565
p_int:  0.999755078
p_ni:  0.000238813
p_wrong:  0.000006109
Data Source:  BioPlex
ITGA8
Tbio
Novelty:  0.0220023
p_int:  0.984758111
p_ni:  0.015241885
p_wrong:  3e-9
Data Source:  BioPlex
POGLUT1
Tbio
Family:  Enzyme
Novelty:  0.03821516
p_int:  0.969693251
p_ni:  0.03030271
p_wrong:  0.000004039
Data Source:  BioPlex
PCSK1N
Tbio
Novelty:  0.02656799
p_int:  0.954832278
p_ni:  0.000096695
p_wrong:  0.045071027
Data Source:  BioPlex
HAPLN3
Tbio
Novelty:  0.19545048
p_int:  0.935911023
p_ni:  0.009692549
p_wrong:  0.054396428
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.912240337
p_ni:  0.087759663
Data Source:  BioPlex
ITGA7
Tbio
Novelty:  0.01243073
p_int:  0.846206416
p_ni:  0.153712377
p_wrong:  0.000081207
Data Source:  BioPlex
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.843864155
p_ni:  0.156135835
p_wrong:  1e-8
Data Source:  BioPlex
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 3 of 3
PNP
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
CCKAR
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
Pathways (23)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of proteins
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
1
1.1
88.1
self reported educational attainment
1
1
1
54.4
mathematical ability
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
88.1
self reported educational attainment
1
54.4
mathematical ability
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone marrow stromal cell antigen 1
VGNC:572
461126
Macaque
bone marrow stromal cell antigen 1
722848
Mouse
MGI:105370
12182
Rat
RGD:620344
81506
Dog
bone marrow stromal cell antigen 1
VGNC:38541
488820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone marrow stromal cell antigen 1
Macaque
bone marrow stromal cell antigen 1
Mouse
Rat
Dog
bone marrow stromal cell antigen 1
Publication Statistics
PubMed Score 81.58
PubMed score by year
PubTator Score 78.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title