You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
BSPRY
B box and SPRY domain-containing protein

Protein Summary
Description
May regulate epithelial calcium transport by inhibiting TRPV5 activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374183
  • ENSP00000363298
  • ENSG00000119411
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.8
gene perturbation
0.69
cell type or tissue
0.51
PubMedID
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
NCS1
Tbio
Novelty:  0.0051468
p_int:  0.999999956
p_ni:  4.4e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
CEP55
Tbio
Novelty:  0.01328073
p_int:  0.999999852
p_ni:  1.48e-7
Data Source:  BioPlex
DEAF1
Tbio
Family:  TF
Novelty:  0.01070035
p_int:  0.999997368
p_wrong:  0.000002632
Score:  0.282
Data Source:  BioPlex,STRINGDB
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
p_int:  0.999993299
p_ni:  0.0000067
p_wrong:  1e-9
Data Source:  BioPlex
TMF1
Tbio
Novelty:  0.02543575
p_int:  0.9999808
p_ni:  0.000019191
p_wrong:  9e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
HAUS4
Tbio
Novelty:  0.91427982
p_int:  0.999843311
p_ni:  0.000156689
Data Source:  BioPlex
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.999683031
p_ni:  0.000316969
Data Source:  BioPlex
HAUS1
Tbio
Novelty:  0.11356375
p_int:  0.998380856
p_ni:  0.001619144
Data Source:  BioPlex
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.99752677
p_ni:  0.001768564
p_wrong:  0.000704667
Data Source:  BioPlex
HSBP1
Tbio
Novelty:  0.09422832
p_int:  0.995341746
p_ni:  0.004658254
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
1
2
2
72.4
hematocrit
1
1
1
71.2
neutrophil count
1
1
1
69.4
reticulocyte measurement
2
1
2
62.1
reticulocyte count
2
1
2
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
2
72.4
hematocrit
1
71.2
neutrophil count
1
69.4
reticulocyte measurement
2
62.1
reticulocyte count
2
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B-box and SPRY domain containing
VGNC:4627
473027
Macaque
B-box and SPRY domain containing
705322
Mouse
MGI:2177191
192120
Rat
RGD:708400
64027
Dog
B-box and SPRY domain containing
VGNC:49718
481682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B-box and SPRY domain containing
Macaque
B-box and SPRY domain containing
Mouse
Rat
Dog
B-box and SPRY domain containing
Publication Statistics
PubMed Score 3.48
PubMed score by year
PubTator Score 2.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title