Protein Summary
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity). Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, ...more
- ENST00000296452
- ENSP00000296452
- ENSG00000164061
- KIAA0434
- ZNF231
- ZNF231
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase | 0.98 | ||
hub protein | 0.85 | ||
histone modification site profile | 0.81 | ||
cellular component | 0.72 | ||
transcription factor | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 214.74 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 115 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 214.74 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 115 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (162)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (2)
Components (15)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (47)
Items per page:
1 – 5 of 47
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 6 | 7 | 6 | 8.2 | 99.1 | ||||
mathematical ability | 4 | 4 | 5 | 98 | |||||
reticulocyte count | 4 | 4 | 5 | 97.2 | |||||
intelligence | 4 | 9 | 5 | 6.9 | 96.1 | ||||
household income | 2 | 6 | 7 | 93.6 | |||||
Items per page:
1 – 5 of 47
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 6 | 8.2 | 99.1 | ||||
mathematical ability | 5 | 98 | |||||
reticulocyte count | 5 | 97.2 | |||||
intelligence | 5 | 6.9 | 96.1 | ||||
household income | 7 | 93.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | bassoon presynaptic cytomatrix protein | VGNC:11328 | 460375 | |||||
Macaque | bassoon presynaptic cytomatrix protein | 705757 | ||||||
Mouse | MGI:1277955 | 12217 | ||||||
Rat | RGD:2223 | 29138 | ||||||
Dog | bassoon presynaptic cytomatrix protein | VGNC:54578 | 484769 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | bassoon presynaptic cytomatrix protein | |||||
Macaque | bassoon presynaptic cytomatrix protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | bassoon presynaptic cytomatrix protein | |||||
Publication Statistics
PubMed Score 214.74
PubMed score by year
PubTator Score 54.07
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
|---|