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Tchem
BRSK1
Serine/threonine-protein kinase BRSK1

Protein Summary
Description
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, prob ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309383
  • ENSP00000310649
  • ENSG00000160469
  • ENST00000585418
  • ENSP00000467357
  • ENST00000590333
  • ENSP00000468190

Symbol
  • KIAA1811
  • SAD1
  • SADB
  • hSAD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
cellular component
0.64
tissue sample
0.59
biological process
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.61   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.61   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (67)
CAB39
Tbio
Novelty:  0.01592402
Score:  0.953
Data Source:  STRINGDB
MAPT
Tclin
Novelty:  0.00013232
Score:  0.934
Data Source:  STRINGDB
STRADA
Tbio
Family:  Kinase
Novelty:  0.0190243
Score:  0.928
Data Source:  STRINGDB
STK11
Tchem
Family:  Kinase
Novelty:  0.00073247
Score:  0.928
Data Source:  STRINGDB
MAP2
Tbio
Novelty:  0.00068493
Score:  0.917
Data Source:  STRINGDB
STRADB
Tbio
Family:  Kinase
Novelty:  0.03532206
Score:  0.901
Data Source:  STRINGDB
CDC25B
Tchem
Family:  Enzyme
Novelty:  0.00378458
Score:  0.764
Data Source:  STRINGDB
HSPBP1
Tbio
Novelty:  0.01176285
Score:  0.754
Data Source:  STRINGDB
CDC25C
Tchem
Family:  Enzyme
Novelty:  0.00227769
Score:  0.728
Data Source:  STRINGDB
CDR2
Tbio
Novelty:  0.00141419
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
2
4
94.7
platelet crit
2
3
4
89.1
mean corpuscular volume
1
3
3
87.5
platelet count
3
4
4
86.9
appendicular lean mass
3
1
3
81.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
94.7
platelet crit
4
89.1
mean corpuscular volume
3
87.5
platelet count
4
86.9
appendicular lean mass
3
81.3
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BR serine/threonine kinase 1
VGNC:10909
100610477
Macaque
BR serine/threonine kinase 1
700287
Mouse
MGI:2685946
381979
Rat
RGD:1563268
499073
Dog
BR serine/threonine kinase 1
VGNC:53668
484297
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BR serine/threonine kinase 1
Macaque
BR serine/threonine kinase 1
Mouse
Rat
Dog
BR serine/threonine kinase 1
Publication Statistics
PubMed Score 40.61
PubMed score by year
PubTator Score 40.32
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title