Tchem BRS3 Bombesin receptor subtype-3

Protein Summary

Description

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P32247
• BRS-3

Gene Name

• BRS3

Ensembl ID

• ENST00000370648
• ENSP00000359682
• ENSG00000102239

Symbol

• BB3
• BB3R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.61
protein domain	0.58
gene perturbation	0.56
disease perturbation	0.49
ligand (chemical)	0.49

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Bombesin Receptor / Bombesin Receptor Subtype-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.16   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 467   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.16   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 162

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0