Protein Summary
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- ENST00000383829
- ENSP00000373340
- ENSG00000156983
- ENST00000424362
- ENSP00000398863
- ENST00000433861
- ENSP00000402485
- ENST00000457855
- ENSP00000410210
- BR140
- BR140
- IDDDFP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
histone modification site profile | 0.76 | ||
disease perturbation | 0.74 | ||
cell line | 0.69 | ||
transcription factor binding site profile | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.73 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 43 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.73 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 43 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 107
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (107)
Protein-Protein Interactions (96)
MEAF6
Novelty: 0.0914094
p_int: 0.999999772
p_ni: 2.25e-7
p_wrong: 3e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
ARRB1
Novelty: 0.00262758
p_int: 0.99999922
p_ni: 7.76e-7
p_wrong: 4e-9
Score: 0.82
Data Source: BioPlex,STRINGDB
ARRB2
Novelty: 0.00148149
p_int: 0.999998135
p_ni: 0.000001863
p_wrong: 2e-9
Score: 0.65
Data Source: BioPlex,STRINGDB
PLCD4
Family: Enzyme
Novelty: 0.07014141
p_int: 0.999976036
p_ni: 0.000015909
p_wrong: 0.000008055
Data Source: BioPlex
PIP4K2A
Family: Kinase
Novelty: 0.01130885
p_int: 0.999965577
p_ni: 0.000034338
p_wrong: 8.6e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | HATs acetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
HATs acetylate histones | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 1 | 1 | 0 | 9.3 | 73 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 0 | 9.3 | 73 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | bromodomain and PHD finger containing 1 | VGNC:1747 | 460151 | |||||
Macaque | bromodomain and PHD finger containing 1 | 699850 | ||||||
Mouse | MGI:1926033 | 78783 | ||||||
Rat | RGD:1584828 | 679713 | ||||||
Dog | bromodomain and PHD finger containing 1 | VGNC:38533 | 484667 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | bromodomain and PHD finger containing 1 | |||||
Macaque | bromodomain and PHD finger containing 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | bromodomain and PHD finger containing 1 | |||||
Publication Statistics
PubMed Score 34.73
PubMed score by year
PubTator Score 23.36
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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