Tchem BRPF1 Peregrin

Protein Summary

Description

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P55201
• B4DEZ6
• Q7Z6E0
• Q8TCM6
• Q9UHI0

Gene Name

• BRPF1

Ensembl ID

• ENST00000383829
• ENSP00000373340
• ENSG00000156983
• ENST00000424362
• ENSP00000398863
• ENST00000433861
• ENSP00000402485
• ENST00000457855
• ENSP00000410210

Symbol

• BR140
• BR140
• IDDDFP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
histone modification site profile	0.76
disease perturbation	0.74
cell line	0.69
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Peregrin

Protein / Nucleic Acid Binding / Peregrin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.4   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 43   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.4   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 111

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0