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Tbio
BRMS1L
Breast cancer metastasis-suppressor 1-like protein

Protein Summary
Description
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216807
  • ENSP00000216807
  • ENSG00000100916

Symbol
  • BRMS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.81
biological process
0.65
transcription factor
0.59
microRNA
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.999999801
p_ni:  9.9e-8
p_wrong:  1e-7
Score:  0.803
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999623
p_ni:  3.77e-7
Score:  0.835
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.999999352
p_ni:  6.48e-7
Score:  0.964
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999992945
p_ni:  0.000007055
Score:  0.847
Data Source:  BioPlex,STRINGDB
ZNF704
Tdark
Novelty:  0.34442716
p_int:  0.998691141
p_ni:  0.001307512
p_wrong:  0.000001348
Score:  0.547
Data Source:  BioPlex,STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
p_int:  0.99848845
p_ni:  0.001511549
p_wrong:  1e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.995619394
p_ni:  0.004380606
Data Source:  BioPlex
MAX
Tbio
Family:  TF
Novelty:  0.00799068
p_int:  0.971461969
p_ni:  0.028537983
p_wrong:  4.8e-8
Data Source:  BioPlex
MXD1
Tbio
Family:  TF
Novelty:  0.0353468
p_int:  0.969876479
p_ni:  0.030123521
Score:  0.226
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.949270008
p_ni:  0.050729978
p_wrong:  1.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
breast cancer metastasis-suppressor 1 like
467599
Macaque
breast cancer metastasis-suppressor 1 like
695909
Mouse
MGI:1196337
52592
Rat
RGD:1306006
299053
Dog
BRMS1 like transcriptional repressor
VGNC:54778
480292
Species
Name
OMA
EggNOG
Inparanoid
Chimp
breast cancer metastasis-suppressor 1 like
Macaque
breast cancer metastasis-suppressor 1 like
Mouse
Rat
Dog
BRMS1 like transcriptional repressor
Publication Statistics
PubMed Score 80.21
PubMed score by year
PubTator Score 3.89
PubTator score by year
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Related Publications
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PMID
Year
Title