Tbio BRK1 Protein BRICK1

Protein Summary

Description

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).

Uniprot Accession IDs

• Q8WUW1
• B2R5E2
• Q9P082
• BRK1

Gene Name

• BRK1

Ensembl ID

• ENST00000530758
• ENSP00000432472
• ENSG00000254999

Symbol

• C3orf10
• MDS027
• hHBrk1
• C3orf10
• HSPC300

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
virus perturbation	0.95
kinase perturbation	0.81
transcription factor binding site profile	0.78
small molecule perturbation	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.86   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.86   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0