You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BRIX1
Ribosome biogenesis protein BRX1 homolog

Protein Summary
Description
Required for biogenesis of the 60S ribosomal subunit.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336767
  • ENSP00000338862
  • ENSG00000113460

Symbol
  • BRIX
  • BXDC2
  • BRIX
  • BXDC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
histone modification site profile
0.9
transcription factor binding site profile
0.76
transcription factor perturbation
0.74
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.73   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.73   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (430)
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.995561326
p_ni:  0.004438674
Data Source:  BioPlex
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.986967899
p_ni:  0.013032101
Score:  0.384
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.98259998
p_ni:  0.01740002
Score:  0.765
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.981291059
p_ni:  0.018708941
Data Source:  BioPlex
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.977793369
p_ni:  0.022206631
Score:  0.157
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.977741919
p_ni:  0.022258081
Score:  0.486
Data Source:  BioPlex,STRINGDB
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.976203228
p_ni:  0.023796772
Score:  0.982
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.971994432
p_ni:  0.028005568
Score:  0.799
Data Source:  BioPlex,STRINGDB
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.970472719
p_ni:  0.029527281
Score:  0.886
Data Source:  BioPlex,STRINGDB
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.966418319
p_ni:  0.033581681
Score:  0.806
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
2
2
89.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
2
89.9
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRX1, biogenesis of ribosomes
VGNC:3910
461927
Macaque
BRX1, biogenesis of ribosomes
698745
Mouse
MGI:1915082
67832
Rat
RGD:1308508
294799
Dog
BRX1, biogenesis of ribosomes
VGNC:38531
479365
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRX1, biogenesis of ribosomes
Macaque
BRX1, biogenesis of ribosomes
Mouse
Rat
Dog
BRX1, biogenesis of ribosomes
Publication Statistics
PubMed Score 5.73
PubMed score by year
PubTator Score 246.87
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title