You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BRINP3
BMP/retinoic acid-inducible neural-specific protein 3

Protein Summary
Description
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367462
  • ENSP00000356432
  • ENSG00000162670

Symbol
  • DBCCR1L
  • DBCCR1L1
  • FAM5C
  • FAM5C
  • DBCCR1L
  • DBCCR1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
co-expressed gene
0.82
cell type or tissue
0.8
cell line
0.53
disease
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
STIM2
Tbio
Novelty:  0.00446493
p_int:  0.999998394
p_ni:  0.000001606
Data Source:  BioPlex
BRINP2
Tdark
Novelty:  0.5101917
p_int:  0.99991186
p_ni:  0.00008814
Score:  0.849
Data Source:  BioPlex,STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.997153558
p_ni:  0.002830615
p_wrong:  0.000015827
Data Source:  BioPlex
TXNDC15
Tdark
Novelty:  0.23488442
p_int:  0.98664288
p_ni:  0.01335712
Data Source:  BioPlex
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
p_int:  0.979147223
p_ni:  0.020852543
p_wrong:  2.33e-7
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.976358573
p_ni:  0.023641427
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.972499567
p_ni:  0.019636542
p_wrong:  0.007863892
Data Source:  BioPlex
KIAA0232
Tdark
Novelty:  2.37569744
p_int:  0.953478941
p_ni:  0.046502736
p_wrong:  0.000018323
Data Source:  BioPlex
TUBA1A
Tchem
Novelty:  0.01030145
p_int:  0.946278909
p_ni:  0.053721091
Data Source:  BioPlex
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.944401219
p_ni:  0.055598781
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
2
6
83.9
body height
1
1
1
63.1
self reported educational attainment
1
1
1
56
wellbeing measurement
2
1
2
49.5
mathematical ability
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
83.9
body height
1
63.1
self reported educational attainment
1
56
wellbeing measurement
2
49.5
mathematical ability
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BMP/retinoic acid inducible neural specific 3
VGNC:8151
469620
Macaque
BMP/retinoic acid inducible neural specific 3
713093
Mouse
MGI:2443035
215378
Rat
RGD:708421
286901
Dog
BMP/retinoic acid inducible neural specific 3
VGNC:38529
478959
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BMP/retinoic acid inducible neural specific 3
Macaque
BMP/retinoic acid inducible neural specific 3
Mouse
Rat
Dog
BMP/retinoic acid inducible neural specific 3
Publication Statistics
PubMed Score 16.21
PubMed score by year
PubTator Score 12.99
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title