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Tdark
BRINP2
BMP/retinoic acid-inducible neural-specific protein 2

Protein Summary
Description
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361539
  • ENSP00000354481
  • ENSG00000198797

Symbol
  • DBCCR1L2
  • FAM5B
  • KIAA1747
  • FAM5B
  • DBCCR1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.73
gene perturbation
0.59
small molecule perturbation
0.55
histone modification site profile
0.46
PubMedID
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
RDH14
Tdark
Family:  Enzyme
Novelty:  0.35816611
p_int:  0.999944755
p_ni:  0.000055244
p_wrong:  1e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
BRINP3
Tbio
Novelty:  0.07870037
p_int:  0.99991186
p_ni:  0.00008814
Score:  0.849
Data Source:  BioPlex,STRINGDB
ATP5MC1
Tbio
Family:  Enzyme
Novelty:  0.03538978
p_int:  0.996624744
p_ni:  0.003375251
p_wrong:  5e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.980406408
p_ni:  0.019593592
Score:  0.172
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.922015386
p_ni:  0.077984613
Data Source:  BioPlex
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.834365651
p_ni:  0.164054008
p_wrong:  0.001580341
Score:  0.239
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
Score:  0.777
Data Source:  STRINGDB
ASTN1
Tbio
Novelty:  0.03247697
Score:  0.714
Data Source:  STRINGDB
GPR37
Tbio
Family:  GPCR
Novelty:  0.02193644
Score:  0.703
Data Source:  STRINGDB
FGF12
Tbio
Novelty:  0.02094849
Score:  0.699
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
68
8
3
1
1.1
60.2
1
1
0
1.1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
68
1
1.1
60.2
0
1.1
3.4
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BMP/retinoic acid inducible neural specific 2
VGNC:8150
469596
Macaque
BMP/retinoic acid inducible neural specific 2
709377
Mouse
MGI:2443333
240843
Rat
RGD:708419
286895
Dog
BMP/retinoic acid inducible neural specific 2
VGNC:38528
490330
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BMP/retinoic acid inducible neural specific 2
Macaque
BMP/retinoic acid inducible neural specific 2
Mouse
Rat
Dog
BMP/retinoic acid inducible neural specific 2
Publication Statistics
PubMed Score 2.18
PubMed score by year
PubTator Score 1.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title