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Tbio
BRF2
Transcription factor IIIB 50 kDa subunit

Protein Summary
Description
General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220659
  • ENSP00000220659
  • ENSG00000104221

Symbol
  • BRFU
  • BRFU
  • TFIIIB50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.74
cell line
0.59
tissue sample
0.57
cell type or tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.41   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.41   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.999999033
p_ni:  9.67e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.999958245
p_ni:  1.68e-7
p_wrong:  0.000041587
Data Source:  BioPlex
NCAM1
Tbio
Novelty:  0.00020994
p_int:  0.806568176
p_ni:  0.193431824
Score:  0.239
Data Source:  BioPlex,STRINGDB
JUP
Tbio
Novelty:  0.0081803
p_int:  0.76538252
p_ni:  0.23461748
Score:  0.345
Data Source:  BioPlex,STRINGDB
BDP1
Tbio
Novelty:  0.00497963
Score:  0.999
Data Source:  Reactome,STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.993
Data Source:  Reactome,STRINGDB
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
Score:  0.992
Data Source:  STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
Score:  0.978
Data Source:  STRINGDB
POLR3B
Tbio
Family:  Enzyme
Novelty:  0.02526167
Score:  0.977
Data Source:  STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Reactome
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRF2, RNA polymerase III transcription initiation factor subunit
VGNC:1172
746619
Macaque
BRF2, RNA polymerase III transcription initiation factor subunit
698758
Mouse
MGI:1913903
66653
Rat
RGD:1308817
306542
Dog
BRF2, RNA polymerase III transcription initiation factor subunit
VGNC:38524
608026
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRF2, RNA polymerase III transcription initiation factor subunit
Macaque
BRF2, RNA polymerase III transcription initiation factor subunit
Mouse
Rat
Dog
BRF2, RNA polymerase III transcription initiation factor subunit
Publication Statistics
PubMed Score 2.41
PubMed score by year
PubTator Score 24.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title