Tbio BRF1 Transcription factor IIIB 90 kDa subunit

Protein Summary

Description

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q92994
• B3KU36
• B4DIG5
• B7Z2N3
• F5H5Z7
• F8WA46
• Q13223
• Q3SYD9
• Q5PR24
• Q6IQ02
• Q96KX3
• Q9HCW6
• Q9HCW7
• Q9HCW8
• TFIIIB90

Gene Name

• BRF1

Ensembl ID

• ENST00000327359
• ENSP00000329029
• ENSG00000185024
• ENST00000379937
• ENSP00000369269
• ENST00000392557
• ENSP00000376340
• ENST00000440513
• ENSP00000388877
• ENST00000446501
• ENSP00000389859
• ENST00000547530
• ENSP00000448387
• ENST00000548421
• ENSP00000446707

Symbol

• BRF
• GTF3B
• TAF3B2
• TAF3C
• BRF
• CFDS
• hBRF
• BRF-1
• GTF3B
• TAF3C
• TAF3B2
• TF3B90
• TAFIII90
• TFIIIB90
• HEL-S-76p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
histone modification site profile	0.79
hub protein	0.75
transcription factor	0.75
small molecule perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Iiib 90 Kda Subunit

DTO Classes

Protein / Transcription Factor / Transcription Factor Iiib 90 Kda Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.25   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.25   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0