Tchem BRDT Bromodomain testis-specific protein

Protein Summary

Description

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q58F21
• A6NF68
• B7Z811
• B7Z890
• B7ZAX7
• D3DT32
• O14789
• Q05DQ4
• Q6P5T1
• Q7Z4A6
• Q8IWI6

Gene Name

• BRDT

Ensembl ID

• ENST00000362005
• ENSP00000354568
• ENSG00000137948
• ENST00000370389
• ENSP00000359416
• ENST00000394530
• ENSP00000378038
• ENST00000399546
• ENSP00000387822
• ENST00000402388
• ENSP00000384051

Symbol

• CT9
• BRD6
• SPGF21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.9
biological process	0.73
cell type or tissue	0.68
PubMedID	0.57
co-expressed gene	0.52

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Reader / Bromodomain / Bromodomain Testis-specific Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.92   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.92   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1