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Tbio
BRD8
Bromodomain-containing protein 8

Protein Summary
Description
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the remov ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230901
  • ENSP00000230901
  • ENSG00000112983
  • ENST00000254900
  • ENSP00000254900
  • ENST00000411594
  • ENSP00000394330

Symbol
  • SMAP
  • SMAP2
  • SMAP
  • p120
  • SMAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
co-expressed gene
0.99
disease perturbation
0.99
transcription factor perturbation
0.94
histone modification site profile
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.19   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.19   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  0.999999474
p_ni:  5.26e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
MORF4L2
Tbio
Novelty:  0.09897629
p_int:  0.999998961
p_ni:  0.000001039
Score:  0.99
Data Source:  BioPlex,STRINGDB
MRGBP
Tbio
Novelty:  0.09537142
p_int:  0.999993966
p_ni:  0.000006034
Score:  0.996
Data Source:  BioPlex,STRINGDB
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999938357
p_ni:  0.000061643
Score:  0.751
Data Source:  BioPlex,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.999833156
p_ni:  0.000166844
Score:  0.991
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999830763
p_ni:  0.000169237
Score:  0.987
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.99980062
p_ni:  0.00019938
Score:  0.971
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999778084
p_ni:  0.000221916
Score:  0.728
Data Source:  BioPlex,STRINGDB
FOXR1
Tbio
Family:  TF
Novelty:  0.20300395
p_int:  0.999762611
p_ni:  0.000237389
Score:  0.852
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.999659498
p_ni:  0.000340502
Score:  0.983
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
96.4
appendicular lean mass
1
1
1
62.5
self reported educational attainment
1
1
1
20.5
mathematical ability
1
1
1
20.5
QT interval
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
96.4
appendicular lean mass
1
62.5
self reported educational attainment
1
20.5
mathematical ability
1
20.5
QT interval
1
6.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 8
VGNC:3909
462090
Macaque
bromodomain containing 8
716492
Mouse
MGI:1925906
78656
Rat
RGD:1307003
291691
Horse
bromodomain containing 8
VGNC:15886
100062423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 8
Macaque
bromodomain containing 8
Mouse
Rat
Horse
bromodomain containing 8
Publication Statistics
PubMed Score 15.19
PubMed score by year
PubTator Score 26.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title