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Tchem
BRD3
Bromodomain-containing protein 3

Protein Summary
Description
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303407
  • ENSP00000305918
  • ENSG00000169925
  • ENST00000371834
  • ENSP00000360900

Symbol
  • KIAA0043
  • RING3L
  • ORFX
  • RING3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.93
kinase perturbation
0.91
virus perturbation
0.85
kinase
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 290.3   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 290.3   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 294
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (294)
CHEMBL3220922
Rendered image for CHEMBL3220922
LY 294002
Rendered image for LY 294002
CHEMBL4173488
Rendered image for CHEMBL4173488
Mivebresib
Rendered image for Mivebresib
US9458145, 1020-18
Rendered image for US9458145, 1020-18
CHEMBL4171228
Rendered image for CHEMBL4171228
CHEMBL4063051
Rendered image for CHEMBL4063051
CHEMBL2177300
Rendered image for CHEMBL2177300
CHEMBL3786012
Rendered image for CHEMBL3786012
Apabetalone
Rendered image for Apabetalone
Protein-Protein Interactions (104)
FAM90A1
Tdark
Novelty:  0.95155075
p_int:  1
Score:  0.811
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999709
p_ni:  2.88e-7
p_wrong:  4e-9
Score:  0.274
Data Source:  BioPlex,STRINGDB
BRD2
Tchem
Family:  Epigenetic
Novelty:  0.00531003
p_int:  0.99999957
p_ni:  4.25e-7
p_wrong:  5e-9
Score:  0.922
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999980529
p_ni:  0.000019464
p_wrong:  7e-9
Score:  0.326
Data Source:  BioPlex,STRINGDB
IGHA2
Tbio
p_int:  0.963956369
p_ni:  0.035953946
p_wrong:  0.000089684
Data Source:  BioPlex
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
Score:  0.93
Data Source:  STRINGDB
HLA-DMA
Tbio
Novelty:  0.00405566
Score:  0.878
Data Source:  STRINGDB
BRD4
Tchem
Family:  Epigenetic
Novelty:  0.0013933
Score:  0.859
Data Source:  STRINGDB
NUTM1
Tbio
Novelty:  0.00390466
Score:  0.811
Data Source:  STRINGDB
HLA-DOA
Tbio
Novelty:  0.01222732
Score:  0.801
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
2
3
94.4
mean platelet volume
2
3
4
93.1
reticulocyte measurement
3
4
4
92.4
neutrophil count
3
3
3
90.5
eosinophil percentage of leukocytes
2
2
2
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3
94.4
mean platelet volume
4
93.1
reticulocyte measurement
4
92.4
neutrophil count
3
90.5
eosinophil percentage of leukocytes
2
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 3
VGNC:4626
464830
Macaque
bromodomain containing 3
713107
Mouse
MGI:1914632
67382
Rat
RGD:1308925
362092
Dog
bromodomain containing 3
480682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 3
Macaque
bromodomain containing 3
Mouse
Rat
Dog
bromodomain containing 3
Publication Statistics
PubMed Score 290.30
PubMed score by year
PubTator Score 36.35
PubTator score by year
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Related Publications
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PMID
Year
Title