BRD3
Bromodomain-containing protein 3
Protein Summary
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
- ENST00000303407
- ENSP00000305918
- ENSG00000169925
- ENST00000371834
- ENSP00000360900
- KIAA0043
- RING3L
- ORFX
- RING3L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
kinase perturbation | 0.91 | ||
virus perturbation | 0.85 | ||
kinase | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.55 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 348 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.55 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 348 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 307
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0