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Tchem
BRD2
Bromodomain-containing protein 2

Protein Summary
Description
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374825
  • ENSP00000363958
  • ENSG00000204256
  • ENST00000374831
  • ENSP00000363964
  • ENST00000383108
  • ENSP00000372588
  • ENSG00000234507
  • ENST00000395287
  • ENSP00000378702
  • ENST00000399527
  • ENSP00000382443
  • ENSG00000215077
  • ENST00000399528
  • ENSP00000382444
  • ENST00000399529
  • ENSP00000382445
  • ENST00000414731
  • ENSP00000391246
  • ENSG00000234704
  • ENST00000436979
  • ENSP00000405634
  • ENSG00000235307
  • ENST00000438194
  • ENSP00000401791
  • ENST00000442863
  • ENSP00000410994
  • ENST00000448067
  • ENSP00000412885
  • ENST00000449085
  • ENSP00000409145
  • ENST00000449118
  • ENSP00000399009
  • ENST00000549126
  • ENSP00000449380
  • ENST00000552587
  • ENSP00000449609

Symbol
  • KIAA9001
  • RING3
  • FSH
  • NAT
  • RNF3
  • FSRG1
  • RING3
  • D6S113E
  • O27.1.1
  • BRD2-IT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
drug perturbation
0.87
kinase perturbation
0.84
transcription factor
0.84
phenotype
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.46   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.46   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 292
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0