BRD1
Bromodomain-containing protein 1
Protein Summary
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
- ENST00000216267
- ENSP00000216267
- ENSG00000100425
- ENST00000404034
- ENSP00000384076
- ENST00000404760
- ENSP00000385858
- ENST00000457780
- ENSP00000410042
- BRL
- BRPF2
- BRL
- BRPF1
- BRPF2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (protein) perturbation | 1 | ||
protein domain | 0.99 | ||
co-expressed gene | 0.82 | ||
kinase perturbation | 0.81 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 299.92 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 299.92 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 44
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0