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Tbio
BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

Protein Summary
Description
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322067
  • ENSP00000318852
  • ENSG00000162813
  • ENST00000414869
  • ENSP00000410348
  • ENST00000469520
  • ENSP00000446828
  • ENST00000544404
  • ENSP00000444398

Symbol
  • PIP
  • HEL20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
gene perturbation
0.79
tissue sample
0.74
interacting protein
0.69
transcription factor binding site profile
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.05   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
SDR39U1
Tdark
Family:  Enzyme
Novelty:  0.38626113
p_int:  0.99999788
p_ni:  0.000001862
p_wrong:  2.58e-7
Score:  0.191
Data Source:  BioPlex,STRINGDB
CHDH
Tbio
Family:  Enzyme
Novelty:  0.02147468
p_int:  0.999922883
p_ni:  0.000061236
p_wrong:  0.000015881
Data Source:  BioPlex
FDXR
Tbio
Family:  Enzyme
Novelty:  0.00171588
p_int:  0.999562841
p_ni:  0.000437159
Data Source:  BioPlex
VARS2
Tbio
Family:  Enzyme
Novelty:  0.00941946
p_int:  0.999432726
p_ni:  0.000453519
p_wrong:  0.000113754
Score:  0.185
Data Source:  BioPlex,STRINGDB
GTPBP10
Tbio
Novelty:  0.18563864
p_int:  0.999243175
p_ni:  0.000756748
p_wrong:  7.8e-8
Data Source:  BioPlex
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.998914315
p_ni:  0.001085684
p_wrong:  1e-9
Data Source:  BioPlex
MTG1
Tbio
Family:  Enzyme
Novelty:  0.07182539
p_int:  0.998443203
p_ni:  0.00155229
p_wrong:  0.000004507
Data Source:  BioPlex
POLG
Tchem
Family:  Enzyme
Novelty:  0.00172189
p_int:  0.998205873
p_ni:  0.001794127
p_wrong:  1e-9
Data Source:  BioPlex
ACSF2
Tbio
Family:  Enzyme
Novelty:  0.10280059
p_int:  0.997449201
p_ni:  0.002550718
p_wrong:  8.1e-8
Score:  0.172
Data Source:  BioPlex,STRINGDB
GFM2
Tbio
Novelty:  0.02945848
p_int:  0.997144565
p_ni:  0.002849821
p_wrong:  0.000005615
Score:  0.266
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
83.3
reticulocyte count
3
1
3
71.2
ferritin measurement
1
1
1
59
smoking status measurement
1
1
1
17.8
glomerular filtration rate
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
83.3
reticulocyte count
3
71.2
ferritin measurement
1
59
smoking status measurement
1
17.8
glomerular filtration rate
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3'(2'), 5'-bisphosphate nucleotidase 1
VGNC:6730
457747
Mouse
MGI:1338800
23827
Dog
3'(2'), 5'-bisphosphate nucleotidase 1
VGNC:53113
608525
Horse
3'(2'), 5'-bisphosphate nucleotidase 1
100053608
Cow
3'(2'), 5'-bisphosphate nucleotidase 1
521254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3'(2'), 5'-bisphosphate nucleotidase 1
Mouse
Dog
3'(2'), 5'-bisphosphate nucleotidase 1
Horse
3'(2'), 5'-bisphosphate nucleotidase 1
Cow
3'(2'), 5'-bisphosphate nucleotidase 1
Publication Statistics
PubMed Score 11.05
PubMed score by year
PubTator Score 3.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title