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Tbio
BPIFA2
BPI fold-containing family A member 2

Protein Summary
Description
Has strong antibacterial activity against P. aeruginosa. This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253362
  • ENSP00000253362
  • ENSG00000131050
  • ENST00000354932
  • ENSP00000347012

Symbol
  • C20orf70
  • SPLUNC2
  • PSP
  • SPLUNC2
  • C20orf70
  • bA49G10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
cell type or tissue
0.53
tissue sample
0.44
chemical
0.41
biological term
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999998947
p_ni:  0.000001052
p_wrong:  2e-9
Data Source:  BioPlex
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999998569
p_ni:  0.000001431
Data Source:  BioPlex
RHOBTB1
Tbio
Novelty:  0.02152609
p_int:  0.99999716
p_ni:  0.000002813
p_wrong:  2.7e-8
Data Source:  BioPlex
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
p_int:  0.999984291
p_ni:  0.000015653
p_wrong:  5.6e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.999981139
p_ni:  0.000018785
p_wrong:  7.6e-8
Data Source:  BioPlex
PLEKHG6
Tbio
Novelty:  0.15989022
p_int:  0.999976695
p_ni:  0.000023225
p_wrong:  7.9e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
COG2
Tbio
Novelty:  0.03109287
p_int:  0.999959734
p_ni:  0.000038772
p_wrong:  0.000001494
Data Source:  BioPlex
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.999870228
p_ni:  0.000119633
p_wrong:  0.000010139
Data Source:  BioPlex
KIR2DS2
Tdark
p_int:  0.999810461
p_ni:  0.00017369
p_wrong:  0.00001585
Data Source:  BioPlex
UQCRQ
Tbio
Novelty:  0.04392627
p_int:  0.99965776
p_ni:  0.000320802
p_wrong:  0.000021438
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
87.3
non-melanoma skin carcinoma
1
1
0
1.3
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
87.3
non-melanoma skin carcinoma
0
1.3
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family A member 2
VGNC:6055
743850
Mouse
MGI:97787
19194
Rat
RGD:3431
50585
Dog
BPI fold containing family A member 2
VGNC:38505
608599
Horse
BPI fold containing family A member 2
VGNC:15868
100034112
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family A member 2
Mouse
Rat
Dog
BPI fold containing family A member 2
Horse
BPI fold containing family A member 2
Publication Statistics
PubMed Score 62.44
PubMed score by year
PubTator Score 96.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title