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Tbio
BPIFA1
BPI fold-containing family A member 1

Protein Summary
Description
Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression. This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the uppe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354297
  • ENSP00000346251
  • ENSG00000198183
  • ENST00000375413
  • ENSP00000364562
  • ENST00000375422
  • ENSP00000364571
  • ENST00000618484
  • ENSP00000482297

Symbol
  • LUNX
  • NASG
  • PLUNC
  • SPLUNC1
  • SPURT
  • LUNX
  • NASG
  • PLUNC
  • SPURT
  • SPLUNC1
  • bA49G10.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.62
cell type or tissue
0.61
disease
0.51
cell line
0.43
chemical
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.24   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.24   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
BPIFB3
Tdark
Novelty:  0.2161337
p_int:  1
Score:  0.858
Data Source:  BioPlex,STRINGDB
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999998289
p_ni:  0.000001702
p_wrong:  8e-9
Data Source:  BioPlex
TMEM237
Tdark
Novelty:  0.27005874
p_int:  0.999987032
p_ni:  0.00001237
p_wrong:  5.98e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999982239
p_ni:  0.000011377
p_wrong:  0.000006384
Data Source:  BioPlex
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.999978199
p_ni:  0.000014486
p_wrong:  0.000007315
Score:  0.209
Data Source:  BioPlex,STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.999865191
p_ni:  0.000028069
p_wrong:  0.00010674
Score:  0.169
Data Source:  BioPlex,STRINGDB
HBM
Tdark
Novelty:  0.02658671
p_int:  0.999766769
p_ni:  0.000127855
p_wrong:  0.000105376
Score:  0.163
Data Source:  BioPlex,STRINGDB
COX7B2
Tdark
Family:  Enzyme
Novelty:  0.92736353
Score:  0.8
Data Source:  STRINGDB
BPI
Tbio
Novelty:  0.00229665
Score:  0.784
Data Source:  STRINGDB
BPIFB2
Tbio
Novelty:  0.2051039
Score:  0.736
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
87.3
BMI-adjusted hip circumference
2
2
2
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
87.3
BMI-adjusted hip circumference
2
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family A member 1
VGNC:6054
458177
Macaque
BPI fold containing family A member 1
714509
Mouse
MGI:1338036
18843
Rat
RGD:619818
246238
Dog
BPI fold containing family A member 1
VGNC:38504
609982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family A member 1
Macaque
BPI fold containing family A member 1
Mouse
Rat
Dog
BPI fold containing family A member 1
Publication Statistics
PubMed Score 209.24
PubMed score by year
PubTator Score 119.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title