You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BPI
Bactericidal permeability-increasing protein

Protein Summary
Description
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
protein domain
0.73
tissue sample
0.59
biological term
0.57
cellular component
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.17   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.17   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (162)
DEFA4
Tbio
Novelty:  0.04566082
Score:  0.984
Data Source:  STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.983
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.982
Data Source:  STRINGDB
AZU1
Tbio
Family:  Enzyme
Novelty:  0.00267169
Score:  0.982
Data Source:  STRINGDB
CTSG
Tchem
Family:  Enzyme
Novelty:  0.00102052
Score:  0.974
Data Source:  STRINGDB
CAMP
Tbio
Novelty:  0.00064433
Score:  0.974
Data Source:  STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
Score:  0.972
Data Source:  STRINGDB
PGLYRP1
Tbio
Novelty:  0.00231527
Score:  0.96
Data Source:  STRINGDB
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
Score:  0.94
Data Source:  STRINGDB
LTF
Tbio
Novelty:  0.00114254
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Toll Like Receptor 4 (TLR4) Cascade
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Neutrophil degranulation
Toll Like Receptor 4 (TLR4) Cascade
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
80.2
heart rate
1
1
1
79.1
electrocardiography
1
1
18
71.9
monocyte percentage of leukocytes
1
2
2
66.6
pulse pressure measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
80.2
heart rate
1
79.1
electrocardiography
18
71.9
monocyte percentage of leukocytes
2
66.6
pulse pressure measurement
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bactericidal permeability increasing protein
VGNC:52083
458238
Macaque
bactericidal/permeability-increasing protein
574153
Mouse
MGI:3045315
329547
Rat
RGD:1303179
296321
Dog
bactericidal permeability increasing protein
VGNC:49649
477226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bactericidal permeability increasing protein
Macaque
bactericidal/permeability-increasing protein
Mouse
Rat
Dog
bactericidal permeability increasing protein
Publication Statistics
PubMed Score 403.17
PubMed score by year
PubTator Score 460.29
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title