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Tbio
BPGM
Bisphosphoglycerate mutase

Protein Summary
Description
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344924
  • ENSP00000342032
  • ENSG00000172331
  • ENST00000393132
  • ENSP00000376840
  • ENST00000418040
  • ENSP00000399838

Symbol
  • DPGM
  • ECYT8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
gene perturbation
0.82
histone modification site profile
0.78
transcription factor perturbation
0.68
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
PPM1B
Tchem
Family:  Enzyme
Novelty:  0.02370446
p_int:  0.999875829
p_ni:  0.000124171
Score:  0.183
Data Source:  BioPlex,STRINGDB
KLF16
Tbio
Family:  TF
Novelty:  0.04789753
p_int:  0.999769433
p_ni:  2.1e-8
p_wrong:  0.000230545
Score:  0.63
Data Source:  BioPlex,STRINGDB
NCF2
Tbio
Novelty:  0.00274685
p_int:  0.99966613
p_ni:  0.000333865
p_wrong:  5e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
PGAM2
Tbio
Family:  Enzyme
Novelty:  0.02438933
p_int:  0.989874988
p_ni:  0.003858697
p_wrong:  0.006266315
Score:  0.954
Data Source:  BioPlex,STRINGDB
CTNNBIP1
Tbio
Novelty:  0.05434645
p_int:  0.98885333
p_ni:  0.011146669
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.945729559
p_ni:  0.054270441
Score:  0.319
Data Source:  BioPlex,STRINGDB
FLYWCH2
Tdark
Novelty:  1.44186144
p_int:  0.934306247
p_ni:  0.056965107
p_wrong:  0.008728646
Score:  0.183
Data Source:  BioPlex,STRINGDB
SPANXB1
Tbio
Novelty:  0.19187624
p_int:  0.919203005
p_ni:  0.053354269
p_wrong:  0.027442726
Data Source:  BioPlex
BOD1
Tbio
Novelty:  0.06404805
p_int:  0.797973408
p_ni:  0.201654252
p_wrong:  0.000372339
Score:  0.189
Data Source:  BioPlex,STRINGDB
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.792627465
p_ni:  0.187233676
p_wrong:  0.02013886
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
4
7
97.1
reticulocyte measurement
3
2
3
87
lymphocyte count
2
3
3
80.8
hip circumference
1
1
1
50.6
myeloid white cell count
1
1
1
13.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
97.1
reticulocyte measurement
3
87
lymphocyte count
3
80.8
hip circumference
1
50.6
myeloid white cell count
1
13.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bisphosphoglycerate mutase
VGNC:4279
463746
Macaque
bisphosphoglycerate mutase
706741
Mouse
MGI:1098242
12183
Rat
RGD:735018
296973
Dog
bisphosphoglycerate mutase
VGNC:38502
482704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bisphosphoglycerate mutase
Macaque
bisphosphoglycerate mutase
Mouse
Rat
Dog
bisphosphoglycerate mutase
Publication Statistics
PubMed Score 28.61
PubMed score by year
PubTator Score 58.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title