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Tdark
BORCS6
BLOC-1-related complex subunit 6

Protein Summary
Description
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389017
  • ENSP00000373669
  • ENSG00000196544

Symbol
  • C17orf59
  • PRO2472
  • C17orf59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.45   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.45   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  1
Score:  0.3
Data Source:  BioPlex,STRINGDB
ODF2L
Tdark
Novelty:  0.56986705
p_int:  1
Score:  0.204
Data Source:  BioPlex,STRINGDB
BORCS5
Tdark
Novelty:  0.59333419
p_int:  0.999999994
p_ni:  5e-9
p_wrong:  1e-9
Score:  0.977
Data Source:  BioPlex,STRINGDB
BORCS8
Tdark
Novelty:  1.62939642
p_int:  0.999999952
p_ni:  2.7e-8
p_wrong:  2.1e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
KXD1
Tdark
Novelty:  0.32146379
p_int:  0.999999845
p_ni:  1.55e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCDC57
Tdark
Novelty:  0.2310982
p_int:  0.999999844
p_ni:  1e-9
p_wrong:  1.55e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
BLOC1S1
Tbio
Novelty:  0.02921036
p_int:  0.999999815
p_ni:  1.73e-7
p_wrong:  1.2e-8
Score:  0.966
Data Source:  BioPlex,STRINGDB
CEP250
Tbio
Novelty:  0.08014712
p_int:  0.999999212
p_ni:  7.88e-7
Data Source:  BioPlex
LUZP1
Tbio
Novelty:  0.14991475
p_int:  0.999999085
p_ni:  9.15e-7
p_wrong:  1e-9
Data Source:  BioPlex
UACA
Tbio
Novelty:  0.05853699
p_int:  0.999998859
p_ni:  0.000001141
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1.1
88.6
hematocrit
2
2
2
79.8
mean corpuscular volume
1
1
1
72.9
mathematical ability
3
2
4
66
reticulocyte measurement
2
2
2
60.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
88.6
hematocrit
2
79.8
mean corpuscular volume
1
72.9
mathematical ability
4
66
reticulocyte measurement
2
60.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BLOC-1 related complex subunit 6
VGNC:9223
107969262
Macaque
BLOC-1 related complex subunit 6
716995
Mouse
MGI:1919173
71923
Rat
RGD:1563885
497934
Dog
BLOC-1 related complex subunit 6
VGNC:38501
608122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BLOC-1 related complex subunit 6
Macaque
BLOC-1 related complex subunit 6
Mouse
Rat
Dog
BLOC-1 related complex subunit 6
Publication Statistics
PubMed Score 1.45
PubMed score by year
PubTator Score 1.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title