Tbio BORA Protein aurora borealis

Protein Summary

Description

Required for the activation of AURKA at the onset of mitosis. BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6PGQ7
• B4DQ30
• Q5W0P3
• Q5W0P4
• Q86YC6
• Q96IW9
• Q9H640
• HsBora

Gene Name

• BORA

Ensembl ID

• ENST00000377815
• ENSP00000367046
• ENSG00000136122

Symbol

• C13orf34
• C13orf34

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
virus perturbation	0.88
trait	0.75
kinase	0.68
tissue	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (186)

Explore Interacting Targets

1 – 10 of 186

• See Interactions on String-DB

PLK1

Tchem

Family:  Kinase

Novelty:  0.00062799

p_int:  0.999884819

p_ni:  0.000115181

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

RABGGTB

Tbio

Family:  Enzyme

Novelty:  0.06786314

p_int:  0.999325706

p_ni:  0.000674188

p_wrong:  1.06e-7

Data Source:  BioPlex

TGM2

Tchem

Family:  Enzyme

Novelty:  0.0005293

p_int:  0.990946672

p_ni:  0.009053247

p_wrong:  8e-8

Data Source:  BioPlex

DNA2

Tbio

Family:  Enzyme

Novelty:  0.00195682

p_int:  0.93187279

p_ni:  0.06812721

Score:  0.402

Data Source:  BioPlex,STRINGDB

AARSD1

Tdark

Novelty:  0.75372406

p_int:  0.922733067

p_ni:  0.077266787

p_wrong:  1.46e-7

Data Source:  BioPlex

DNAJB11

Tbio

Novelty:  0.02588745

p_int:  0.919030326

p_ni:  0.080774153

p_wrong:  0.000195521

Score:  0.179

Data Source:  BioPlex,STRINGDB

LYPD4

Tbio

Novelty:  0.00381728

p_int:  0.918299005

p_ni:  0.081495258

p_wrong:  0.000205737

Data Source:  BioPlex

TSHR

Tclin

Family:  GPCR

Novelty:  0.00074972

p_int:  0.909799974

p_ni:  0.090061699

p_wrong:  0.000138328

Score:  0.189

Data Source:  BioPlex,STRINGDB

UBE3D

Tbio

Family:  Enzyme

Novelty:  0.44919491

p_int:  0.907467358

p_ni:  0.092528359

p_wrong:  0.000004284

Score:  0.192

Data Source:  BioPlex,STRINGDB

WNT4

Tbio

Novelty:  0.00276803

p_int:  0.884063548

p_ni:  0.115936451

p_wrong:  1e-9

Score:  0.177

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (5)

PathwayCommons (1)

Cell Cycle (R-HSA-1640170)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	G2/M Transition	184 targets	R-HSA-69275
Reactome	Mitotic G2-G2/M phases	186 targets	R-HSA-453274
Reactome	Regulation of PLK1 Activity at G2/M Transition	87 targets	R-HSA-2565942

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
G2/M Transition	184 targets	R-HSA-69275
Mitotic G2-G2/M phases	186 targets	R-HSA-453274
Regulation of PLK1 Activity at G2/M Transition	87 targets	R-HSA-2565942

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (1)

Processes (5)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1	1	1		71.2
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		32.9
testosterone measurement	EFO_0004908	1	1	1		6.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1		71.2
mean corpuscular hemoglobin concentration	EFO_0004528	1		32.9
testosterone measurement	EFO_0004908	1		6.6

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Cell division
Complete proteome
Mitosis
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration
mean reticulocyte volume
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	bora, aurora kinase A activator	VGNC:9842	467283
Macaque	bora, aurora kinase A activator		693798
Mouse	bora, aurora kinase A activator	MGI:1924994	77744
Rat	bora, aurora kinase A activator	RGD:1309522	306102
Dog	bora, aurora kinase A activator	VGNC:38499	476944

Species	Name	OMA	EggNOG	Inparanoid
Chimp	bora, aurora kinase A activator
Macaque	bora, aurora kinase A activator
Mouse	bora, aurora kinase A activator
Rat	bora, aurora kinase A activator
Dog	bora, aurora kinase A activator

Publication Statistics

PubMed Score 27.01

PubMed score by year

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PubTator Score 16.18

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (12)

Items per page:

10

0 of 0

PMID	Year	Title