Tbio BORA Protein aurora borealis

Protein Summary

Description

Required for the activation of AURKA at the onset of mitosis. BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6PGQ7
• B4DQ30
• Q5W0P3
• Q5W0P4
• Q86YC6
• Q96IW9
• Q9H640
• HsBora

Gene Name

• BORA

Ensembl ID

• ENST00000377815
• ENSP00000367046
• ENSG00000136122

Symbol

• C13orf34
• C13orf34

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
virus perturbation	0.88
trait	0.75
kinase	0.68
tissue	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.73   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.73   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0