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Tbio
BOLA3
BolA-like protein 3

Protein Summary
Description
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1 (PubMed:27532772). This gene encodes a protein that plays an essential role in the production of iron-sulfur (Fe-S) clusters for the normal maturation of lipoate-containing 2-oxoacid dehydrogenases, and for the assembly of the mitochondrial respiratory chain complexes. Mutation in this gene has been associated with multiple mitochondrial dysfunctions syndrome-2. Two alternatively spliced transcript variants encoding different isoforms with distinct subcellular localization have been reported for this gene (PMID:21944046). [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295326
  • ENSP00000295326
  • ENSG00000163170
  • ENST00000327428
  • ENSP00000331369

Symbol
  • MMDS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.9
virus perturbation
0.83
transcription factor binding site profile
0.75
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.6   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.6   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
FAHD2A
Tdark
Family:  Enzyme
Novelty:  0.68981789
p_int:  0.999718928
p_ni:  8.3e-7
p_wrong:  0.000280242
Score:  0.519
Data Source:  BioPlex,STRINGDB
NUDT6
Tbio
Novelty:  0.03648851
p_int:  0.998128289
p_ni:  0.000228031
p_wrong:  0.001643679
Score:  0.28
Data Source:  BioPlex,STRINGDB
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.760296082
p_ni:  0.000005189
p_wrong:  0.239698729
Data Source:  BioPlex
GLRX5
Tbio
Novelty:  0.01166161
Score:  0.999
Data Source:  STRINGDB
BOLA1
Tbio
Novelty:  0.1092583
Score:  0.999
Data Source:  STRINGDB
NFU1
Tbio
Novelty:  0.01465025
Score:  0.933
Data Source:  STRINGDB
CIAPIN1
Tbio
Novelty:  0.01359005
Score:  0.918
Data Source:  STRINGDB
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
Score:  0.917
Data Source:  STRINGDB
BOLA2
Tbio
Novelty:  0.18144236
Score:  0.909
Data Source:  STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
Score:  0.875
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
1
2
57.3
alcohol consumption measurement
2
1
2
56.2
eosinophil percentage of leukocytes
1
1
1
56
smoking status measurement
1
1
1
52
eosinophil count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
57.3
alcohol consumption measurement
2
56.2
eosinophil percentage of leukocytes
1
56
smoking status measurement
1
52
eosinophil count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bolA family member 3
VGNC:10529
459330
Macaque
bolA family member 3
707871
Mouse
MGI:1925903
78653
Rat
RGD:1305975
297388
Dog
bolA family member 3
612287
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bolA family member 3
Macaque
bolA family member 3
Mouse
Rat
Dog
bolA family member 3
Publication Statistics
PubMed Score 19.60
PubMed score by year
PubTator Score 8.28
PubTator score by year
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Related Publications
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PMID
Year
Title