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Tdark
BOD1L1
Biorientation of chromosomes in cell division protein 1-like 1

Protein Summary
Description
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000040738
  • ENSP00000040738
  • ENSG00000038219

Symbol
  • BOD1L
  • FAM44A
  • KIAA1327
  • BOD1L
  • FAM44A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
cell type or tissue
0.87
transcription factor binding site profile
0.86
virus perturbation
0.76
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
p_int:  0.999999418
p_ni:  5.82e-7
Score:  0.877
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999997683
p_ni:  0.000002317
Score:  0.527
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999991603
p_ni:  0.000008397
Score:  0.554
Data Source:  BioPlex,STRINGDB
HCFC2
Tbio
Novelty:  0.12260416
p_int:  0.999891232
p_ni:  0.000108768
Score:  0.578
Data Source:  BioPlex,STRINGDB
EPB41L5
Tbio
Novelty:  0.0391959
p_int:  0.999048744
p_ni:  0.000951256
Score:  0.664
Data Source:  BioPlex,STRINGDB
ZNF784
Tdark
Family:  TF
Novelty:  17.08860759
p_int:  0.99485418
p_ni:  0.00514582
Data Source:  BioPlex
MDK
Tchem
Novelty:  0.00145301
p_int:  0.994747368
p_ni:  0.005252632
Score:  0.55
Data Source:  BioPlex,STRINGDB
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.972138452
p_ni:  0.027861548
Score:  0.199
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.971019301
p_ni:  0.028980699
Data Source:  BioPlex
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
Score:  0.808
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip geometry
1
1
1
62.7
educational attainment
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip geometry
1
62.7
educational attainment
1
12.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
biorientation of chromosomes in cell division 1 like 1
VGNC:6472
461121
Macaque
biorientation of chromosomes in cell division 1 like 1
713697
Mouse
MGI:2444804
665775
Rat
RGD:621413
207118
Dog
biorientation of chromosomes in cell division 1 like 1
VGNC:38496
479089
Species
Name
OMA
EggNOG
Inparanoid
Chimp
biorientation of chromosomes in cell division 1 like 1
Macaque
biorientation of chromosomes in cell division 1 like 1
Mouse
Rat
Dog
biorientation of chromosomes in cell division 1 like 1
Publication Statistics
PubMed Score 3.74
PubMed score by year
PubTator Score 1.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title