Tbio BNIP1 Vesicle transport protein SEC20

Protein Summary

Description

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q12981
• D3DQM3
• D3DQM4
• D3DQM5
• D3DQM6
• O75622
• O75623
• O75624
• Q6K044
• Q96FG4

Gene Name

• BNIP1

Ensembl ID

• ENST00000231668
• ENSP00000231668
• ENSG00000113734
• ENST00000351486
• ENSP00000239215
• ENST00000352523
• ENSP00000239214
• ENST00000393770
• ENSP00000377365

Symbol

• NIP1
• SEC20L
• NIP1
• SEC20
• TRG-8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
disease perturbation	0.95
transcription factor binding site profile	0.83
cellular component	0.78
kinase perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.37   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 472   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.37   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0