You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BNIP1
Vesicle transport protein SEC20

Protein Summary
Description
As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311). Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231668
  • ENSP00000231668
  • ENSG00000113734
  • ENST00000351486
  • ENSP00000239215
  • ENST00000352523
  • ENSP00000239214
  • ENST00000393770
  • ENSP00000377365

Symbol
  • NIP1
  • SEC20L
  • NIP1
  • SEC20
  • TRG-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.95
transcription factor binding site profile
0.83
cellular component
0.78
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.91   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.91   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
SCFD2
Tdark
Novelty:  0.38252131
p_int:  0.999965796
p_ni:  0.000034204
Score:  0.917
Data Source:  BioPlex,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999933652
p_ni:  0.000066348
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.999932207
p_ni:  0.000067793
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.999864016
p_ni:  0.000135974
p_wrong:  9e-9
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.99977514
p_ni:  0.00022486
Score:  0.599
Data Source:  BioPlex,STRINGDB
CCDC107
Tdark
Novelty:  1.10682722
p_int:  0.999246529
p_ni:  0.000753471
Score:  0.186
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.998148647
p_ni:  0.001851353
Score:  0.823
Data Source:  BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty:  0.01845286
p_int:  0.997654335
p_ni:  0.002345663
p_wrong:  2e-9
Data Source:  BioPlex
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.997652941
p_ni:  0.002347059
Data Source:  BioPlex
CLEC12A
Tbio
Novelty:  0.01478908
p_int:  0.991970827
p_ni:  0.008029173
Score:  0.525
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.4
81.7
2
2
0
1.1
76
TPE interval measurement
1
2
2
63.6
PR interval
2
2
0
1.4
60.4
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
81.7
0
1.1
76
TPE interval measurement
2
63.6
PR interval
0
1.4
60.4
self reported educational attainment
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 1
VGNC:6383
740480
Macaque
BCL2 interacting protein 1
703576
Mouse
MGI:109328
224630
Rat
RGD:620799
140932
Dog
BCL2 interacting protein 1
VGNC:38492
609594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 1
Macaque
BCL2 interacting protein 1
Mouse
Rat
Dog
BCL2 interacting protein 1
Publication Statistics
PubMed Score 20.91
PubMed score by year
PubTator Score 30.65
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title