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Tbio
BNC2
Zinc finger protein basonuclin-2

Protein Summary
Description
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. This gene encodes a conserved zinc finger protein. The encoded protein functions in skin color saturation. Mutations in this gene are associated with facial pigmented spots. This gene is also associated with susceptibility to adolescent idiopathic scoliosis. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380672
  • ENSP00000370047
  • ENSG00000173068
  • ENST00000484726
  • ENSP00000431516

Symbol
  • BSN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
transcription factor perturbation
0.74
PubMedID
0.71
disease
0.65
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.44   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.44   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.999999992
p_wrong:  8e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999997933
p_ni:  8.4e-8
p_wrong:  0.000001982
Data Source:  BioPlex
SRSF2
Tbio
Novelty:  0.00207072
Score:  0.756
Data Source:  STRINGDB
TUSC1
Tbio
Novelty:  0.12487295
Score:  0.688
Data Source:  STRINGDB
CNTLN
Tbio
Novelty:  0.0044959
Score:  0.661
Data Source:  STRINGDB
SH3GL2
Tbio
Novelty:  0.0188955
Score:  0.645
Data Source:  STRINGDB
DALRD3
Tdark
Novelty:  0.5378666
Score:  0.63
Data Source:  STRINGDB
WDR6
Tbio
Novelty:  0.20146637
Score:  0.609
Data Source:  STRINGDB
TYRP1
Tbio
Family:  Enzyme
Novelty:  0.00062138
Score:  0.589
Data Source:  STRINGDB
OFCC1
Tdark
Novelty:  0.0424264
Score:  0.563
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
8
94.4
keratinocyte carcinoma
1
3
0
1.1
92.8
3
4
3
1.1
91.7
hair color
2
3
0
1.1
91
suntan
1
2
2
88.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
94.4
keratinocyte carcinoma
0
1.1
92.8
3
1.1
91.7
hair color
0
1.1
91
suntan
2
88.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basonuclin 2
VGNC:4625
465005
Macaque
basonuclin 2
713291
Mouse
MGI:2443805
242509
Rat
RGD:1310694
298189
Dog
basonuclin 2
VGNC:38491
612979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basonuclin 2
Macaque
basonuclin 2
Mouse
Rat
Dog
basonuclin 2
Publication Statistics
PubMed Score 61.44
PubMed score by year
PubTator Score 30.00
PubTator score by year
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Related Publications
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PMID
Year
Title