Tbio BMT2 S-adenosylmethionine sensor upstream of mTORC1

Protein Summary

Description

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).

Uniprot Accession IDs

• Q1RMZ1
• Q8N3D0
• Q96MV7

Gene Name

• BMT2

Ensembl ID

• ENST00000297145
• ENSP00000297145
• ENSG00000164603

Symbol

• C7orf60
• SAMTOR
• SAMTOR
• C7orf60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.78   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 10   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.78   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (49)

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1 – 10 of 49

• See Interactions on String-DB

DEPDC5

Tbio

Novelty:  0.0177511

p_int:  0.999999999

p_ni:  1e-9

Score:  0.867

Data Source:  BioPlex,Reactome,STRINGDB

SZT2

Tbio

Novelty:  0.06995258

p_int:  0.999999943

p_ni:  5.7e-8

Score:  0.828

Data Source:  BioPlex,Reactome,STRINGDB

C12orf66

Tbio

Novelty:  1.38775963

p_int:  0.999999918

p_ni:  1.9e-8

p_wrong:  6.3e-8

Score:  0.873

Data Source:  BioPlex,Reactome,STRINGDB

NPRL2

Tbio

Family:  Enzyme

Novelty:  0.02848752

p_int:  0.999993196

p_ni:  0.000006802

p_wrong:  2e-9

Score:  0.704

Data Source:  BioPlex,Reactome,STRINGDB

NPRL3

Tbio

Family:  Enzyme

Novelty:  0.0110744

p_int:  0.999983104

p_ni:  0.000016895

Score:  0.617

Data Source:  BioPlex,Reactome,STRINGDB

ACAD11

Tbio

Family:  Enzyme

Novelty:  0.22908145

p_int:  0.999956998

p_ni:  0.000043002

Data Source:  BioPlex

ITFG2

Tbio

Novelty:  0.41720651

p_int:  0.999949759

p_ni:  0.000050241

Score:  0.681

Data Source:  BioPlex,Reactome,STRINGDB

KPTN

Tbio

Novelty:  0.06841936

p_int:  0.999471227

p_ni:  0.000528581

p_wrong:  1.92e-7

Score:  0.667

Data Source:  BioPlex,Reactome,STRINGDB

REN

Tclin

Family:  Enzyme

Novelty:  0.00002435

p_int:  0.995473012

p_ni:  0.004036101

p_wrong:  0.000490887

Score:  0.204

Data Source:  BioPlex,STRINGDB

PER1

Tbio

Novelty:  0.01290576

p_int:  0.995286347

p_ni:  0.004713653

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (2)

Components (1)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
S-adenosyl-L-methionine binding	Inferred from Direct Assay (IDA)	UniProtKB
rRNA (adenine) methyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Methyltransferase
Reference proteome
S-adenosyl-L-methionine
Transferase

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	base methyltransferase of 25S rRNA 2	MGI:2141466	101148
Rat	base methyltransferase of 25S rRNA 2 homolog	RGD:1588441	500034
Dog	base methyltransferase of 25S rRNA 2 homolog	VGNC:38488	475290
Horse	base methyltransferase of 25S rRNA 2 homolog [Source:HGNC Symbol;Acc:HGNC:26475]
Cow	base methyltransferase of 25S rRNA 2 homolog	VGNC:26528	538658

Species	Name	OMA	EggNOG	Inparanoid
Mouse	base methyltransferase of 25S rRNA 2
Rat	base methyltransferase of 25S rRNA 2 homolog
Dog	base methyltransferase of 25S rRNA 2 homolog
Horse	base methyltransferase of 25S rRNA 2 homolog [Source:HGNC Symbol;Acc:HGNC:26475]
Cow	base methyltransferase of 25S rRNA 2 homolog

Publication Statistics

PubMed Score 17.78

PubMed score by year

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PubTator Score 7.56

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title