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Tbio
BMT2
S-adenosylmethionine sensor upstream of mTORC1

Protein Summary
Description
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297145
  • ENSP00000297145
  • ENSG00000164603

Symbol
  • C7orf60
  • SAMTOR
  • SAMTOR
  • C7orf60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
DEPDC5
Tbio
Novelty:  0.0177511
p_int:  0.999999999
p_ni:  1e-9
Score:  0.867
Data Source:  BioPlex,Reactome,STRINGDB
SZT2
Tbio
Novelty:  0.06995258
p_int:  0.999999943
p_ni:  5.7e-8
Score:  0.828
Data Source:  BioPlex,Reactome,STRINGDB
C12orf66
Tbio
Novelty:  1.38775963
p_int:  0.999999918
p_ni:  1.9e-8
p_wrong:  6.3e-8
Score:  0.873
Data Source:  BioPlex,Reactome,STRINGDB
NPRL2
Tbio
Family:  Enzyme
Novelty:  0.02848752
p_int:  0.999993196
p_ni:  0.000006802
p_wrong:  2e-9
Score:  0.704
Data Source:  BioPlex,Reactome,STRINGDB
NPRL3
Tbio
Family:  Enzyme
Novelty:  0.0110744
p_int:  0.999983104
p_ni:  0.000016895
Score:  0.617
Data Source:  BioPlex,Reactome,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.999956998
p_ni:  0.000043002
Data Source:  BioPlex
ITFG2
Tbio
Novelty:  0.41720651
p_int:  0.999949759
p_ni:  0.000050241
Score:  0.681
Data Source:  BioPlex,Reactome,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.999471227
p_ni:  0.000528581
p_wrong:  1.92e-7
Score:  0.667
Data Source:  BioPlex,Reactome,STRINGDB
REN
Tclin
Family:  Enzyme
Novelty:  0.00002435
p_int:  0.995473012
p_ni:  0.004036101
p_wrong:  0.000490887
Score:  0.204
Data Source:  BioPlex,STRINGDB
PER1
Tbio
Novelty:  0.01290576
p_int:  0.995286347
p_ni:  0.004713653
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2141466
101148
Rat
RGD:1588441
500034
Dog
base methyltransferase of 25S rRNA 2 homolog
VGNC:38488
475290
Horse
base methyltransferase of 25S rRNA 2 homolog [Source:HGNC Symbol;Acc:HGNC:26475]
Cow
base methyltransferase of 25S rRNA 2 homolog
VGNC:26528
538658
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
base methyltransferase of 25S rRNA 2 homolog
Horse
base methyltransferase of 25S rRNA 2 homolog [Source:HGNC Symbol;Acc:HGNC:26475]
Cow
base methyltransferase of 25S rRNA 2 homolog
Publication Statistics
PubMed Score 17.78
PubMed score by year
PubTator Score 7.56
PubTator score by year
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Related Publications
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PMID
Year
Title