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Tchem
BMPR1B
Bone morphogenetic protein receptor type-1B

Protein Summary
Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264568
  • ENSP00000264568
  • ENSG00000138696
  • ENST00000394931
  • ENSP00000378389
  • ENST00000440890
  • ENSP00000401907
  • ENST00000509540
  • ENSP00000421671
  • ENST00000512312
  • ENSP00000425444
  • ENST00000515059
  • ENSP00000426617

Symbol
  • ALK6
  • AMDD
  • BDA2
  • ALK-6
  • BDA1D
  • CDw293
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
biological process
0.89
small molecule
0.89
gene perturbation
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.76   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 606   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.76   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 606   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (130)
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
p_int:  0.995461649
p_ni:  0.000175482
p_wrong:  0.004362869
Score:  0.224
Data Source:  BioPlex,STRINGDB
EVA1C
Tbio
Novelty:  0.45928677
p_int:  0.994086216
p_ni:  0.000204657
p_wrong:  0.005709127
Score:  0.255
Data Source:  BioPlex,STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.997
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.995
Data Source:  Reactome,STRINGDB
BMP7
Tbio
Novelty:  0.00049424
Score:  0.987
Data Source:  STRINGDB
SMAD9
Tbio
Family:  TF
Novelty:  0.00285887
Score:  0.985
Data Source:  Reactome,STRINGDB
BMP6
Tbio
Novelty:  0.00197133
Score:  0.984
Data Source:  STRINGDB
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
Score:  0.98
Data Source:  Reactome,STRINGDB
SMAD6
Tbio
Family:  TF
Novelty:  0.00488425
Score:  0.98
Data Source:  Reactome,STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.979
Data Source:  STRINGDB
Pathways (31)
Signal Transduction (R-HSA-162582)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
57.6
systolic blood pressure
1
1
1
55.2
2
2
2
51.4
2
1
2
46.5
hemoglobin measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
57.6
systolic blood pressure
1
55.2
2
51.4
2
46.5
hemoglobin measurement
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein receptor type 1B
VGNC:7044
461683
Macaque
bone morphogenetic protein receptor type 1B
705474
Mouse
MGI:107191
12167
Dog
bone morphogenetic protein receptor type 1B
VGNC:38485
478484
Horse
bone morphogenetic protein receptor type 1B
VGNC:15852
100053554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein receptor type 1B
Macaque
bone morphogenetic protein receptor type 1B
Mouse
Dog
bone morphogenetic protein receptor type 1B
Horse
bone morphogenetic protein receptor type 1B
Publication Statistics
PubMed Score 123.76
PubMed score by year
PubTator Score 68.44
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title