Tchem BMP4 Bone morphogenetic protein 4

Protein Summary

Description

Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P12644
• Q9UM80
• BMP-4

Gene Name

• BMP4

Ensembl ID

• ENST00000245451
• ENSP00000245451
• ENSG00000125378
• ENST00000417573
• ENSP00000394165
• ENST00000558984
• ENSP00000454134
• ENST00000559087
• ENSP00000453485

Symbol

• BMP2B
• DVR4
• ZYME
• BMP2B
• OFC11
• BMP2B1
• MCOPS6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
PubMedID	1
gene perturbation	0.97
cell type or tissue	0.79

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Bone Morphogenetic Protein 4

DTO Classes

Protein / Signaling / Growth Factor / Bone Morphogenetic Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2487.77   (req: < 5)

Gene RIFs: 387   (req: <= 3)

Antibodies: 767   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2487.77   (req: >= 5)

Gene RIFs: 387   (req: > 3)

Antibodies: 767   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 166

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0