Tchem BMP4 Bone morphogenetic protein 4

Protein Summary

Description

Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P12644
• Q9UM80
• BMP-4

Gene Name

• BMP4

Ensembl ID

• ENST00000245451
• ENSP00000245451
• ENSG00000125378
• ENST00000417573
• ENSP00000394165
• ENST00000558984
• ENSP00000454134
• ENST00000559087
• ENSP00000453485

Symbol

• BMP2B
• DVR4
• ZYME
• BMP2B
• OFC11
• BMP2B1
• MCOPS6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
PubMedID	1
gene perturbation	0.97
cell type or tissue	0.79

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Bone Morphogenetic Protein 4

DTO Classes

Protein / Signaling / Growth Factor / Bone Morphogenetic Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2268.87   (req: < 5)

Gene RIFs: 306   (req: <= 3)

Antibodies: 767   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2268.87   (req: >= 5)

Gene RIFs: 306   (req: > 3)

Antibodies: 767   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 166

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (13)

Explore Active Ligands

1 – 10 of 13

dorsomorphin

BMP4Tchem

pIC50 : 9

CHEMBL513147

BMP4Tchem

pIC50 : 9.03

CHEMBL511563

BMP4Tchem

pIC50 : 8.17

CHEMBL467972

BMP4Tchem

pIC50 : 8.3

CHEMBL469053

BMP4Tchem

pIC50 : 8

CHEMBL469054

BMP4Tchem

pIC50 : 7.05

CHEMBL467560

BMP4Tchem

pIC50 : 6.82

CHEMBL467345

BMP4Tchem

pIC50 : 6.6

CHEMBL468399

BMP4Tchem

pIC50 : 6.46

CHEMBL466765

BMP4Tchem

pIC50 : 6.35

Protein-Protein Interactions (557)

Explore Interacting Targets

1 – 10 of 557

• See Interactions on String-DB

DCAF16

Tdark

Novelty:  0.35666992

p_int:  0.999778343

p_ni:  0.000214832

p_wrong:  0.000006825

Score:  0.158

Data Source:  BioPlex,STRINGDB

SLC22A23

Tbio

Family:  Transporter

Novelty:  0.23405744

p_int:  0.999521467

p_ni:  0.000458655

p_wrong:  0.000019878

Score:  0.188

Data Source:  BioPlex,STRINGDB

TWSG1

Tbio

Novelty:  0.00255544

p_int:  0.997020278

p_ni:  0.002955861

p_wrong:  0.000023861

Score:  0.894

Data Source:  BioPlex,STRINGDB

UBE2O

Tbio

Novelty:  0.07084123

p_int:  0.949168643

p_ni:  0.050831357

Score:  0.161

Data Source:  BioPlex,STRINGDB

PDP1

Tbio

Family:  Enzyme

Novelty:  0.00442352

p_int:  0.934183698

p_ni:  0.065816302

Score:  0.204

Data Source:  BioPlex,STRINGDB

SUFU

Tbio

Novelty:  0.00475249

p_int:  0.815304419

p_ni:  0.184695476

p_wrong:  1.05e-7

Score:  0.343

Data Source:  BioPlex,STRINGDB

PROS1

Tbio

Novelty:  0.00275184

p_int:  0.768656534

p_ni:  0.231343466

Score:  0.272

Data Source:  BioPlex,STRINGDB

CALR

Tbio

Novelty:  0.0004479

p_int:  0.758634768

p_ni:  0.241365232

Score:  0.373

Data Source:  BioPlex,STRINGDB

BMPR1A

Tchem

Family:  Kinase

Novelty:  0.00343928

Score:  0.998

Data Source:  STRINGDB

BMPR1B

Tchem

Family:  Kinase

Novelty:  0.00698763

Score:  0.997

Data Source:  STRINGDB

Nearest Tclin Targets (2)

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Upstream (1)

Downstream (1)

1 – 1 of 1

THRA

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  1

1: Thyroid hormone signaling pathway

Pathways (83)

Reactome (7)

KEGG (8)

PathwayCommons (11)

WikiPathways (57)

Elastic fibre formation (R-HSA-1566948)

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5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Elastic fibre formation	41 targets	R-HSA-1566948
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Molecules associated with elastic fibres	30 targets	R-HSA-2129379
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Elastic fibre formation	41 targets	R-HSA-1566948
Extracellular matrix organization	297 targets	R-HSA-1474244
Metabolism of proteins	2050 targets	R-HSA-392499
Molecules associated with elastic fibres	30 targets	R-HSA-2129379
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (169)

Functions (7)

Components (3)

Processes (159)

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10

1 – 7 of 7

GO Term	Evidence	Assigned by
BMP receptor binding	Inferred from Direct Assay (IDA)	MGI
chemoattractant activity	Inferred from Direct Assay (IDA)	UniProtKB
cytokine activity	Inferred from Direct Assay (IDA)	MGI
co-receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
transforming growth factor beta receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
growth factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
heparin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	11	17		99.6
FEV/FEC ratio	EFO_0004713	2	3	3		91.4
colorectal cancer	EFO_0005842	5	4	0	1.1	90
colorectal adenoma	EFO_0005406	1	3	0	1.1	87.2
refractive error measurement	EFO_0007814	1	2	2		78.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	17		99.6
FEV/FEC ratio	EFO_0004713	3		91.4
colorectal cancer	EFO_0005842	0	1.1	90
colorectal adenoma	EFO_0005406	0	1.1	87.2
refractive error measurement	EFO_0007814	2		78.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Chondrogenesis
Cleavage on pair of basic residues
Complete proteome
Cytokine
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
BMI-adjusted waist circumference
colorectal adenoma
colorectal cancer
cortical surface area measurement
cup-to-disc ratio measurement
FEV/FEC ratio
glomerular filtration rate
heel bone mineral density
optic disc size measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	bone morphogenetic protein 4	VGNC:3472	107968170
Macaque	bone morphogenetic protein 4		694618
Mouse	bone morphogenetic protein 4	MGI:88180	12159
Rat	bone morphogenetic protein 4	RGD:2213	25296
Dog	bone morphogenetic protein 4	VGNC:38480	490695

Species	Name	OMA	EggNOG	Inparanoid
Chimp	bone morphogenetic protein 4
Macaque	bone morphogenetic protein 4
Mouse	bone morphogenetic protein 4
Rat	bone morphogenetic protein 4
Dog	bone morphogenetic protein 4

Publication Statistics

PubMed Score 2268.87

PubMed score by year

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PubTator Score 875.35

PubTator score by year

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Related Publications

Text Mined References (405)

GeneRif Annotations (306)

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PMID	Year	Title