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Tchem
BMP1
Bone morphogenetic protein 1

Protein Summary
Description
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX. This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306349
  • ENSP00000306121
  • ENSG00000168487
  • ENST00000306385
  • ENSP00000305714
  • ENST00000471755
  • ENSP00000428665
  • ENST00000520970
  • ENSP00000428332
  • ENST00000521385
  • ENSP00000430406

Symbol
  • PCOLC
  • PCP
  • TLD
  • OI13
  • PCP2
  • PCOLC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.95
disease perturbation
0.83
transcription factor perturbation
0.68
molecular function
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.4   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 332.4   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 307
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (145)
TLL2
Tchem
Novelty:  0.04888109
p_int:  0.999999985
p_wrong:  1.5e-8
Score:  0.21
Data Source:  BioPlex,STRINGDB
TLL1
Tchem
Novelty:  0.02261325
p_int:  0.999999968
p_wrong:  3.2e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
CLIP1
Tbio
Novelty:  0.00399891
p_int:  0.999999574
p_ni:  3.99e-7
p_wrong:  2.7e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
RMND5B
Tbio
Novelty:  0.08447048
p_int:  0.999998709
p_ni:  0.000001261
p_wrong:  3e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
NBN
Tbio
Novelty:  0.00759456
p_int:  0.99999689
p_ni:  0.00000311
Score:  0.195
Data Source:  BioPlex,STRINGDB
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.999993052
p_ni:  0.000006948
Data Source:  BioPlex
KIF2C
Tbio
Novelty:  0.00498643
p_int:  0.999890439
p_ni:  0.000109561
Data Source:  BioPlex
GID4
Tbio
Novelty:  0.05252674
p_int:  0.999119473
p_ni:  0.000880527
Data Source:  BioPlex
MRE11
Tbio
Novelty:  0.01038348
p_int:  0.999071688
p_ni:  0.000928312
Score:  0.187
Data Source:  BioPlex,STRINGDB
CSTF3
Tbio
Novelty:  0.05260909
p_int:  0.999041059
p_ni:  0.000958941
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
Anchoring fibril formation (R-HSA-2214320)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring fibril formation
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Name
Explore in Pharos
Explore in Source
Anchoring fibril formation
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen formation
Crosslinking of collagen fibrils
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
94.5
low density lipoprotein cholesterol measurement
4
4
4
74
apolipoprotein B measurement
2
2
2
72.8
serum alanine aminotransferase measurement
1
1
1
63.4
3
2
3
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
94.5
low density lipoprotein cholesterol measurement
4
74
apolipoprotein B measurement
2
72.8
serum alanine aminotransferase measurement
1
63.4
3
63
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 1
VGNC:1173
464042
Macaque
bone morphogenetic protein 1
707596
Mouse
MGI:88176
12153
Rat
RGD:620739
83470
Dog
bone morphogenetic protein 1
VGNC:38475
100856514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 1
Macaque
bone morphogenetic protein 1
Mouse
Rat
Dog
bone morphogenetic protein 1
Publication Statistics
PubMed Score 332.40
PubMed score by year
PubTator Score 2391.55
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title