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Tbio
BMF
Bcl-2-modifying factor

Protein Summary
Description
May play a role in apoptosis. Isoform 1 seems to be the main initiator. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354670
  • ENSP00000346697
  • ENSG00000104081
  • ENST00000397573
  • ENSP00000380703
  • ENST00000431415
  • ENSP00000396511
  • ENST00000558774
  • ENSP00000453913
  • ENST00000559701
  • ENSP00000453919
  • ENST00000561282
  • ENSP00000453522
  • ENST00000561360
  • ENSP00000453892
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
transcription factor
0.77
PubMedID
0.68
cellular component
0.64
biological process
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.93   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.93   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.976
Data Source:  Reactome,STRINGDB
BCL2
Tclin
Novelty:  0.00608635
Score:  0.974
Data Source:  Reactome,STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.943
Data Source:  STRINGDB
DYNLL2
Tbio
Novelty:  0.11209457
Score:  0.943
Data Source:  Reactome,STRINGDB
MCL1
Tchem
Novelty:  0.00046181
Score:  0.924
Data Source:  STRINGDB
BCL2A1
Tchem
Novelty:  0.00088899
Score:  0.915
Data Source:  STRINGDB
BCL2L2
Tchem
Novelty:  0.00430896
Score:  0.879
Data Source:  STRINGDB
BCL2L11
Tchem
Novelty:  0.00055914
Score:  0.857
Data Source:  STRINGDB
HRK
Tbio
Novelty:  0.00304072
Score:  0.836
Data Source:  STRINGDB
BIK
Tbio
Novelty:  0.0046334
Score:  0.8
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (111)
Activation of BH3-only proteins (R-HSA-114452)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of BMF and translocation to mitochondria
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
Intrinsic Pathway for Apoptosis
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of BMF and translocation to mitochondria
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Intrinsic Pathway for Apoptosis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
5
95.8
testosterone measurement
4
2
4
89.9
sex hormone-binding globulin measurement
4
2
4
82
reticulocyte measurement
2
2
2
76.7
serum alanine aminotransferase measurement
2
1
1
8.6
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
95.8
testosterone measurement
4
89.9
sex hormone-binding globulin measurement
4
82
reticulocyte measurement
2
76.7
serum alanine aminotransferase measurement
1
8.6
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Bcl2 modifying factor
VGNC:6460
453323
Macaque
Bcl2 modifying factor
706239
Mouse
MGI:2176433
171543
Rat
RGD:628658
246142
Dog
Bcl2 modifying factor
VGNC:38474
607313
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Bcl2 modifying factor
Macaque
Bcl2 modifying factor
Mouse
Rat
Dog
Bcl2 modifying factor
Publication Statistics
PubMed Score 89.93
PubMed score by year
PubTator Score 24.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title