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Tbio
BLZF1
Golgin-45

Protein Summary
Description
Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329281
  • ENSP00000327541
  • ENSG00000117475
  • ENST00000367807
  • ENSP00000356781
  • ENST00000367808
  • ENSP00000356782

Symbol
  • JEM1
  • JEM1
  • JEM-1
  • JEM-1s
  • GOLGIN-45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.87
kinase perturbation
0.84
tissue sample
0.75
transcription factor binding site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
GORASP2
Tbio
Novelty:  0.02121907
p_int:  0.999999972
p_ni:  2.8e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.605
Data Source:  BioPlex,STRINGDB
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.999997697
p_ni:  0.000002303
Score:  0.185
Data Source:  BioPlex,STRINGDB
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.999996939
p_ni:  0.000003061
Score:  0.986
Data Source:  BioPlex,STRINGDB
BTN2A1
Tbio
Novelty:  0.02259329
p_int:  0.999985318
p_ni:  0.000014682
Score:  0.183
Data Source:  BioPlex,STRINGDB
PF4
Tbio
Novelty:  0.00038481
p_int:  0.999975835
p_ni:  0.000024165
Data Source:  BioPlex
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999941951
p_ni:  0.000058049
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999935115
p_ni:  0.000064862
p_wrong:  2.3e-8
Data Source:  BioPlex
TMED3
Tbio
Novelty:  0.06696993
p_int:  0.999885947
p_ni:  0.000114053
Score:  0.709
Data Source:  BioPlex,STRINGDB
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.997318585
p_ni:  0.002676784
p_wrong:  0.000004631
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Golgi Cisternae Pericentriolar Stack Reorganization
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Golgi Cisternae Pericentriolar Stack Reorganization
M Phase
Mitotic Prophase
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
87.9
QT interval
2
2
3
1.3
84.3
electrocardiography
1
1
21
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
87.9
QT interval
3
1.3
84.3
electrocardiography
21
77.7
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper nuclear factor 1
VGNC:457
469574
Macaque
basic leucine zipper nuclear factor 1
700930
Mouse
MGI:1201607
66352
Rat
RGD:1562452
498266
Dog
basic leucine zipper nuclear factor 1
VGNC:38473
490354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper nuclear factor 1
Macaque
basic leucine zipper nuclear factor 1
Mouse
Rat
Dog
basic leucine zipper nuclear factor 1
Publication Statistics
PubMed Score 21.76
PubMed score by year
PubTator Score 32.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title