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Tbio
BLVRA
Biliverdin reductase A

Protein Summary
Description
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265523
  • ENSP00000265523
  • ENSG00000106605
  • ENST00000402924
  • ENSP00000385757

Symbol
  • BLVR
  • BVR
  • BVR
  • BLVR
  • BVRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.9
kinase perturbation
0.88
disease perturbation
0.87
histone modification site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.18   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.18   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
TBX20
Tbio
Family:  TF
Novelty:  0.01290983
p_int:  0.999897779
p_ni:  0.00010193
p_wrong:  2.91e-7
Score:  0.737
Data Source:  BioPlex,STRINGDB
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.999876658
p_ni:  0.000123308
p_wrong:  3.3e-8
Score:  0.2
Data Source:  BioPlex,STRINGDB
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.99986797
p_ni:  0.00013203
Score:  0.197
Data Source:  BioPlex,STRINGDB
RTN4IP1
Tbio
Family:  Enzyme
Novelty:  0.01274213
p_int:  0.999124128
p_ni:  0.00001209
p_wrong:  0.000863781
Score:  0.252
Data Source:  BioPlex,STRINGDB
RRAGB
Tbio
Novelty:  0.02279777
p_int:  0.998348086
p_ni:  0.001599869
p_wrong:  0.000052045
Score:  0.163
Data Source:  BioPlex,STRINGDB
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.996393393
p_ni:  0.003606607
Score:  0.229
Data Source:  BioPlex,STRINGDB
OSBPL6
Tbio
Novelty:  0.25692861
p_int:  0.973550742
p_ni:  0.026449235
p_wrong:  2.3e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
TLN1
Tbio
Novelty:  0.00803981
p_int:  0.967641596
p_ni:  0.032358404
Score:  0.222
Data Source:  BioPlex,STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.951798789
p_ni:  0.048201211
Score:  0.16
Data Source:  BioPlex,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.834498123
p_ni:  0.16550174
p_wrong:  1.37e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (47)
Heme degradation (R-HSA-189483)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme degradation
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme degradation
Metabolism
Metabolism of porphyrins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
peak insulin response measurement
1
2
2
17.4
pulmonary non-tuberculous mycobacterial infection
1
1
0
1.3
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
peak insulin response measurement
2
17.4
pulmonary non-tuberculous mycobacterial infection
0
1.3
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
biliverdin reductase A
700980
Mouse
MGI:88170
109778
Rat
RGD:620721
116599
Dog
biliverdin reductase A
VGNC:38471
475867
Horse
biliverdin reductase A
VGNC:15840
100064761
Species
Name
OMA
EggNOG
Inparanoid
Macaque
biliverdin reductase A
Mouse
Rat
Dog
biliverdin reductase A
Horse
biliverdin reductase A
Publication Statistics
PubMed Score 216.18
PubMed score by year
PubTator Score 76.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title