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Tbio
BLOC1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

Protein Summary
Description
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421). This gene encodes a protein with multiple functions. The encoded protein has been found in association with the centrosome, shown to co-localize with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370372
  • ENSP00000359398
  • ENSG00000196072
  • ENST00000441611
  • ENSP00000410865
  • ENST00000614731
  • ENSP00000481847

Symbol
  • BLOS2
  • CEAP
  • CEAP
  • BLOS2
  • BORCS2
  • CEAP11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
kinase perturbation
0.84
cellular component
0.81
interacting protein
0.72
biological process
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999999992
p_ni:  8e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
BORCS7
Tbio
Novelty:  0.14135922
p_int:  0.999999892
p_ni:  1.06e-7
p_wrong:  2e-9
Score:  0.951
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999998078
p_ni:  0.000001863
p_wrong:  5.8e-8
Score:  0.963
Data Source:  BioPlex,STRINGDB
TRIM69
Tbio
Family:  Enzyme
Novelty:  0.18807436
p_int:  0.999996525
p_ni:  0.000003475
Score:  0.656
Data Source:  BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty:  0.01845286
p_int:  0.999925877
p_ni:  0.000074123
Score:  0.984
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999923518
p_ni:  0.000076481
p_wrong:  1e-9
Score:  0.679
Data Source:  BioPlex,STRINGDB
BCAS4
Tbio
Novelty:  0.11759439
p_int:  0.999827984
p_ni:  0.000172016
Score:  0.854
Data Source:  BioPlex,STRINGDB
TSKS
Tbio
Family:  Enzyme
Novelty:  0.0886446
p_int:  0.999531597
p_ni:  0.000468219
p_wrong:  1.84e-7
Score:  0.524
Data Source:  BioPlex,STRINGDB
TEX35
Tbio
Novelty:  0.5605055
p_int:  0.998980243
p_ni:  0.001019363
p_wrong:  3.94e-7
Score:  0.539
Data Source:  BioPlex,STRINGDB
SYBU
Tbio
Novelty:  0.06029092
p_int:  0.998925546
p_ni:  0.001063127
p_wrong:  0.000011327
Score:  0.583
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genotoxicity pathway
WikiPathways
Genotoxicity pathway
WikiPathways
Genotoxicity pathway
Name
Explore in Pharos
Explore in Source
Genotoxicity pathway
Genotoxicity pathway
Genotoxicity pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
1
6
94.2
metabolite measurement
1
1
1
93.6
lysophosphatidylcholine measurement
3
3
4
12.5
92.2
heel bone mineral density
3
1
4
89.3
total cholesterol measurement
3
3
3
88.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
6
94.2
metabolite measurement
1
93.6
lysophosphatidylcholine measurement
4
12.5
92.2
heel bone mineral density
4
89.3
total cholesterol measurement
3
88.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
biogenesis of lysosomal organelles complex 1 subunit 2
709877
Mouse
MGI:1920939
73689
Rat
RGD:1306551
293938
Dog
biogenesis of lysosomal organelles complex 1 subunit 2
VGNC:38467
612865
Horse
biogenesis of lysosomal organelles complex 1 subunit 2
VGNC:51478
100060519
Species
Name
OMA
EggNOG
Inparanoid
Macaque
biogenesis of lysosomal organelles complex 1 subunit 2
Mouse
Rat
Dog
biogenesis of lysosomal organelles complex 1 subunit 2
Horse
biogenesis of lysosomal organelles complex 1 subunit 2
Publication Statistics
PubMed Score 40.31
PubMed score by year
PubTator Score 484.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title