Protein Summary
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]
- ENST00000261714
- ENSP00000261714
- ENSG00000108578
- BH
- BMH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.91 | ||
histone modification site profile | 0.82 | ||
cell type or tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.52 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.52 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (63)
NUDT12
Family: Enzyme
Novelty: 0.18740719
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.869
Data Source: BioPlex,STRINGDB
KERA
Novelty: 0.00789599
p_int: 0.990459728
p_ni: 0.009540272
Score: 0.874
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (5)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 2 | 1 | 2 | 56.8 | |||||
total cholesterol measurement | 1 | 2 | 2 | 39.5 | |||||
visceral adipose tissue measurement | 1 | 1 | 1 | 33.1 | |||||
QRS complex | 1 | 1 | 0 | 115.6 | 28.1 | ||||
QRS amplitude | 1 | 1 | 0 | 115.6 | 28.1 | ||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 2 | 56.8 | |||||
total cholesterol measurement | 2 | 39.5 | |||||
visceral adipose tissue measurement | 1 | 33.1 | |||||
QRS complex | 0 | 115.6 | 28.1 | ||||
QRS amplitude | 0 | 115.6 | 28.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | bleomycin hydrolase | VGNC:9147 | 454555 | |||||
Macaque | bleomycin hydrolase | 712275 | ||||||
Mouse | MGI:1345186 | 104184 | ||||||
Rat | RGD:1304668 | 287552 | ||||||
Dog | bleomycin hydrolase | VGNC:38465 | 480635 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | bleomycin hydrolase | |||||
Macaque | bleomycin hydrolase | |||||
Mouse | ||||||
Rat | ||||||
Dog | bleomycin hydrolase | |||||
Publication Statistics
PubMed Score 114.52
PubMed score by year
PubTator Score 68.57
PubTator score by year
Related Publications
Text Mined References (48)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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