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Tbio
BLCAP
Bladder cancer-associated protein

Protein Summary
Description
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373537
  • ENSP00000362637
  • ENSG00000166619
  • ENST00000397131
  • ENSP00000380320
  • ENST00000397134
  • ENSP00000380323
  • ENST00000397135
  • ENSP00000380324
  • ENST00000397137
  • ENSP00000380326
  • ENST00000414542
  • ENSP00000397172
  • ENST00000432507
  • ENSP00000414973
  • ENST00000649668
  • ENSP00000497610

Symbol
  • BC10
  • BC10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.92
transcription factor binding site profile
0.9
transcription factor
0.81
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.71   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.71   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
NNAT
Tbio
Novelty:  0.01079637
Score:  0.903
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.782
Data Source:  STRINGDB
CYFIP2
Tbio
Novelty:  0.01910939
Score:  0.649
Data Source:  STRINGDB
CTNNBL1
Tbio
Novelty:  0.0189038
Score:  0.641
Data Source:  STRINGDB
ATP10A
Tbio
Family:  Transporter
Novelty:  0.03552478
Score:  0.637
Data Source:  STRINGDB
ANKZF1
Tbio
Novelty:  0.24799526
Score:  0.627
Data Source:  STRINGDB
ADAR
Tbio
Family:  Enzyme
Novelty:  0.00135586
Score:  0.621
Data Source:  STRINGDB
COG3
Tbio
Novelty:  0.02746711
Score:  0.595
Data Source:  STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.587
Data Source:  STRINGDB
FBLIM1
Tbio
Novelty:  0.0332985
Score:  0.586
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1858907
53619
Rat
RGD:621666
171113
Dog
BLCAP, apoptosis inducing factor
VGNC:54698
100685444
Horse
BLCAP, apoptosis inducing factor
VGNC:54695
100055373
Cow
BLCAP, apoptosis inducing factor
VGNC:54701
281649
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
BLCAP, apoptosis inducing factor
Horse
BLCAP, apoptosis inducing factor
Cow
BLCAP, apoptosis inducing factor
Publication Statistics
PubMed Score 66.71
PubMed score by year
PubTator Score 24.80
PubTator score by year
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Related Publications
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PMID
Year
Title