You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
BIRC8
Baculoviral IAP repeat-containing protein 8

Protein Summary
Description
Protects against apoptosis mediated by BAX.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426466
  • ENSP00000412957
  • ENSG00000163098

Symbol
  • ILP2
  • ILP2
  • ILP-2
  • hILP2
  • RNF136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
biological process
0.75
cell line
0.41
cell type or tissue
0.41
tissue sample
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.93   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.93   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (38)
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.999974832
p_ni:  0.000025168
Score:  0.771
Data Source:  BioPlex,STRINGDB
HTRA2
Tbio
Family:  Enzyme
Novelty:  0.00343249
p_int:  0.999805316
p_ni:  0.000194684
Score:  0.596
Data Source:  BioPlex,STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
p_int:  0.993750372
p_ni:  0.006249628
Score:  0.927
Data Source:  BioPlex,STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
p_int:  0.943350768
p_ni:  0.056649232
Score:  0.513
Data Source:  BioPlex,STRINGDB
CASP9
Tchem
Family:  Enzyme
Novelty:  0.00023687
p_int:  0.916097331
p_wrong:  0.083902669
Score:  0.965
Data Source:  BioPlex,STRINGDB
CDK19
Tchem
Family:  Kinase
Novelty:  0.03132669
p_int:  0.846760049
p_ni:  0.153239951
Score:  0.161
Data Source:  BioPlex,STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.928
Data Source:  STRINGDB
BIRC7
Tchem
Novelty:  0.00420245
Score:  0.827
Data Source:  STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.683
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.633
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
Name
Explore in Pharos
Explore in Source
Small cell lung cancer
Small cell lung cancer
Small cell lung cancer
Small cell lung cancer
Small cell lung cancer
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
39.6
sex hormone-binding globulin measurement
2
1
2
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
39.6
sex hormone-binding globulin measurement
2
13.1
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 16.93
PubMed score by year
PubTator Score 6.47
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title