Tchem BIRC7 Baculoviral IAP repeat-containing protein 7

Protein Summary

Description

Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing. This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q96CA5
• Q9BQV0
• Q9H2A8
• Q9HAP7

Gene Name

• BIRC7

Ensembl ID

• ENST00000217169
• ENSP00000217169
• ENSG00000101197
• ENST00000342412
• ENSP00000345213

Symbol

• KIAP
• LIVIN
• MLIAP
• RNF50
• KIAP
• LIVIN
• MLIAP
• RNF50
• ML-IAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
molecular function	0.81
biological term	0.74
cell type or tissue	0.68
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Baculoviral Iap Repeat-containing Protein 7

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Baculoviral Iap Repeat-containing Protein 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.89   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 609   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 289.89   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0