Tchem BIRC5 Baculoviral IAP repeat-containing protein 5

Protein Summary

Description

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• O15392
• A2SUH6
• B2R4R1
• Q2I3N8
• Q4VGX0
• Q53F61
• Q5MGC6
• Q6FHL2
• Q75SP2
• Q9P2W8

Gene Name

• BIRC5

Ensembl ID

• ENST00000374948
• ENSP00000364086
• ENSG00000089685
• ENST00000590449
• ENSP00000465868
• ENST00000590925
• ENSP00000467336
• ENST00000592734
• ENSP00000466617

Symbol

• API4
• IAP4
• API4
• EPR-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
co-expressed gene	0.95
kinase perturbation	0.95
transcription factor perturbation	0.94
biological term	0.93

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Baculoviral Iap Repeat-containing Protein 5

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Baculoviral Iap Repeat-containing Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.91   (req: < 5)

Gene RIFs: 1228   (req: <= 3)

Antibodies: 1598   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.91   (req: >= 5)

Gene RIFs: 1228   (req: > 3)

Antibodies: 1598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0