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Tchem
BIRC3
Baculoviral IAP repeat-containing protein 3

Protein Summary
Description
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263464
  • ENSP00000263464
  • ENSG00000023445
  • ENST00000532808
  • ENSP00000432907
  • ENST00000615299
  • ENSP00000481903

Symbol
  • API2
  • MIHC
  • RNF49
  • AIP1
  • API2
  • MIHC
  • CIAP2
  • HAIP1
  • HIAP1
  • IAP-1
  • MALT2
  • RNF49
  • c-IAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological process
0.96
gene perturbation
0.95
chemical
0.93
biological term
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.64   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 635   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.64   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 635   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 105
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (253)
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.999
Data Source:  Reactome,STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.997
Data Source:  Reactome,STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
Score:  0.995
Data Source:  STRINGDB
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.995
Data Source:  Reactome,STRINGDB
RIPK2
Tchem
Family:  Kinase
Novelty:  0.00574043
Score:  0.993
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.993
Data Source:  STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
Score:  0.991
Data Source:  STRINGDB
CD40
Tchem
Novelty:  0.0002836
Score:  0.991
Data Source:  Reactome,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.988
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.988
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
TNF
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  7
more:  3 more common pathways
Pathways (151)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Reactome
IKK complex recruitment mediated by RIP1
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Death Receptor Signalling
Deubiquitination
IKK complex recruitment mediated by RIP1
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
2
2
71
matrix metalloproteinase 1 measurement
1
1
1
64.4
birth weight
1
1
1
56.4
parental genotype effect measurement
1
1
1
56.4
alkaline phosphatase measurement
1
1
1
11.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
71
matrix metalloproteinase 1 measurement
1
64.4
birth weight
1
56.4
parental genotype effect measurement
1
56.4
alkaline phosphatase measurement
1
11.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
baculoviral IAP repeat containing 3
VGNC:11266
451507
Mouse
MGI:1197007
11796
Rat
RGD:621282
78971
Dog
baculoviral IAP repeat containing 3
VGNC:53305
489433
Horse
baculoviral IAP repeat containing 3
VGNC:15833
100068894
Species
Name
OMA
EggNOG
Inparanoid
Chimp
baculoviral IAP repeat containing 3
Mouse
Rat
Dog
baculoviral IAP repeat containing 3
Horse
baculoviral IAP repeat containing 3
Publication Statistics
PubMed Score 493.64
PubMed score by year
PubTator Score 415.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title